假单胞菌属N.C.I.B. 10590对胆酸的降解作用。
The degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590.
作者信息
Tenneson M E, Baty J D, Bilton R F, Mason A N
出版信息
Biochem J. 1979 Dec 15;184(3):613-8. doi: 10.1042/bj1840613.
Abstract
The microbial degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590 was studied, and two major products were isolated and identified as 7 alpha, 12 beta-dihydroxyandrosta-1,4-diene-3,17-dione and 7 alpha, 12 alpha-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid. Four minor products were isolated and evidence is given for the following structures: 7 alpha, 12 alpha-dihydroxyandrosta-1,4-diene-3,17-dione, 12 beta-hydroxyandrosta-1,4,6-triene-3,17-dione, 7 alpha, 12 beta, 17 beta-trihydroxyandrosta-1,4-dien-3-one and 7 alpha, 12 alpha-dihydroxy-3-oxopregn-4-ene-20-carboxylic acid. The significance of the production of the steroid products is discussed, along with the possible enzymic mechanisms responsible for their production.
摘要
研究了假单胞菌属N.C.I.B. 10590对胆酸的微生物降解作用，分离出两种主要产物，鉴定为7α, 12β-二羟基雄甾-1,4-二烯-3,17-二酮和7α, 12α-二羟基-3-氧代孕甾-1,4-二烯-20-羧酸。分离出四种次要产物，并给出了以下结构的证据：7α, 12α-二羟基雄甾-1,4-二烯-3,17-二酮、12β-羟基雄甾-1,4,6-三烯-3,17-二酮、7α, 12β, 17β-三羟基雄甾-1,4-二烯-3-酮和7α, 12α-二羟基-3-氧代孕-4-烯-20-羧酸。讨论了甾体产物产生的意义以及负责其产生的可能酶促机制。
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