铜绿假单胞菌ATCC 31752对牛胆汁进行需氧分解代谢的主要中性产物。

The major neutral products of the aerobic catabolism of cattle bile by Pseudomonas sp. ATCC 31752.

作者信息

Park R J

出版信息

Steroids. 1981 Oct;38(4):383-95. doi: 10.1016/0039-128x(81)90073-8.

Abstract

Pseudomonas sp. ATCC 31752 grows aerobically on cattle bile in a fermenter utilising the bile acid conjugates as a carbon source. Under conditions of limited aeration several steroid catabolites accumulate and these were harvested in good yield. Evidence is presented to show that these compounds are the novel compounds 12 beta-hydroxy-4, 6-androsta diene-3, 17-dione (VII) and 7 alpha, 12 beta-dihydroxy-4-androstene-3, 17-dione (VIII) together with the known bile acid catabolites 7 alpha, 12 beta-dihydroxy-1,4-androstadiene-3, 17-dione (IV), 7 alpha-hydroxy-1, 4-androstadiene-3, 17-dione (V) and 12 beta-hydroxy-1, 4-androstadiene-3, 17-dione (VI).

摘要

铜绿假单胞菌ATCC 31752在发酵罐中利用胆汁酸共轭物作为碳源，在有氧条件下于牛胆汁中生长。在通气受限的条件下，几种甾体分解代谢物会积累，并且这些代谢物能以良好的产量收获。有证据表明，这些化合物是新型化合物12β-羟基-4,6-雄甾二烯-3,17-二酮（VII）和7α,12β-二羟基-4-雄甾烯-3,17-二酮（VIII），以及已知的胆汁酸分解代谢物7α,12β-二羟基-1,4-雄甾二烯-3,17-二酮（IV）、7α-羟基-1,4-雄甾二烯-3,17-二酮（V）和12β-羟基-1,4-雄甾二烯-3,17-二酮（VI）。