• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

青少年和年轻成人原发性骨肉瘤冷冻自体移植物重建的临床疗效。

Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults.

机构信息

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1, Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.

出版信息

Sci Rep. 2021 Aug 27;11(1):17291. doi: 10.1038/s41598-021-96162-5.

DOI:10.1038/s41598-021-96162-5
PMID:34453061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8397769/
Abstract

Age affects the clinical outcomes of cancer treatment, including those for bone sarcoma. Successful reconstruction using frozen autograft after excision of bone sarcoma has been reported; however, little is known about the clinical outcomes of frozen autograft reconstruction according to age. The purpose was to evaluate the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults (AYAs) that was 15 to 39 years of age. A total of 37 AYA patients with primary bone sarcoma on the appendicular skeleton were enrolled in this study. The mean follow-up period was 89 months. The graft survival (GS), overall survival (OS), recurrence-free survival (RFS), complications and the function were retrospectively evaluated using medical records. The 10-year GS, OS, and RFS rates were 76%, 84%, and 79%, respectively. Bone union was achieved with a rate of 94% within 1 year after surgery, and nonunion (n = 1) and fracture (n = 2) were infrequently observed. Graft removal was performed in 7 cases, and the most common reason for the removal was infection (n = 5). The Musculoskeletal Tumor Society score was excellent in 23 cases of the available 29 cases. Frozen autograft reconstruction for AYAs showed excellent clinical outcomes, although the long-term follow-up is required.

摘要

年龄会影响癌症治疗的临床结果，包括骨肉瘤的治疗结果。有报道称，切除骨肉瘤后使用冷冻自体移植物进行成功重建；然而，根据年龄对冷冻自体移植物重建的临床结果知之甚少。本研究旨在评估冷冻自体移植物重建的临床结果，重点关注 15 至 39 岁的骨骼成熟青少年和年轻成人（AYA）。本研究共纳入了 37 例四肢原发性骨肉瘤的 AYA 患者。平均随访时间为 89 个月。回顾性分析了病历，以评估移植物存活率（GS）、总体生存率（OS）、无复发生存率（RFS）、并发症和功能。10 年 GS、OS 和 RFS 率分别为 76%、84%和 79%。术后 1 年内，骨愈合率达到 94%，且非愈合（n=1）和骨折（n=2）的发生率较低。7 例患者进行了移植物取出，最常见的移除原因是感染（n=5）。29 例中可评估的 23 例中，肌肉骨骼肿瘤学会评分优秀。尽管需要长期随访，但冷冻自体移植物重建对于 AYA 显示出了极好的临床结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/d77e809761e8/41598_2021_96162_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/74bb0461d07e/41598_2021_96162_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/c6fafe10632d/41598_2021_96162_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/1947535ca789/41598_2021_96162_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/96240909124b/41598_2021_96162_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/d77e809761e8/41598_2021_96162_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/74bb0461d07e/41598_2021_96162_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/c6fafe10632d/41598_2021_96162_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/1947535ca789/41598_2021_96162_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/96240909124b/41598_2021_96162_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/957f/8397769/d77e809761e8/41598_2021_96162_Fig5_HTML.jpg

相似文献

1
Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults.青少年和年轻成人原发性骨肉瘤冷冻自体移植物重建的临床疗效。
Sci Rep. 2021 Aug 27;11(1):17291. doi: 10.1038/s41598-021-96162-5.
2
Intercalary frozen autograft for reconstruction of malignant bone and soft tissue tumours.用于恶性骨与软组织肿瘤重建的间置冷冻自体移植物。
Int Orthop. 2017 Jul;41(7):1481-1487. doi: 10.1007/s00264-017-3446-x. Epub 2017 Mar 25.
3
Are Pasteurized Autografts Durable for Reconstructions After Bone Tumor Resections?经巴氏消毒的自体移植物在骨肿瘤切除后重建中是否持久？
Clin Orthop Relat Res. 2018 Sep;476(9):1728-1737. doi: 10.1007/s11999.0000000000000100.
4
Pedicle frozen autograft-prosthesis composite reconstructions for malignant bone tumors of the proximal femur.带蒂冷冻骨-假体复合重建治疗股骨近端恶性骨肿瘤。
BMC Musculoskelet Disord. 2020 Feb 6;21(1):81. doi: 10.1186/s12891-020-3112-0.
5
The outcomes of reconstruction using frozen autograft combined with iodine-coated implants for malignant bone tumors: compared with non-coated implants.使用冷冻自体骨移植联合碘涂层植入物治疗恶性骨肿瘤的重建结果：与未涂层植入物的比较。
Jpn J Clin Oncol. 2016 Aug;46(8):735-40. doi: 10.1093/jjco/hyw065. Epub 2016 May 20.
6
The long-term outcome following the use of frozen autograft treated with liquid nitrogen in the management of bone and soft-tissue sarcomas.冷冻自体移植物在骨和软组织肉瘤治疗中应用的长期结果。
Bone Joint J. 2014 Apr;96-B(4):555-61. doi: 10.1302/0301-620X.96B4.32629.
7
Long-term outcomes of an extracorporeal irradiated autograft for limb salvage operations in musculoskeletal tumours: over ten years’ observation.肢体骨肉瘤保肢手术中体外辐照自体移植物的长期结果：超过十年的观察。
Bone Joint J. 2019 Sep;101-B(9):1151-1159. doi: 10.1302/0301-620X.101B9.BJJ-2019-0090.R1.
8
Pedicle frozen autograft reconstruction in malignant bone tumors.恶性骨肿瘤的椎弓根自体骨冷冻重建
J Orthop Sci. 2010 May;15(3):340-9. doi: 10.1007/s00776-010-1458-0. Epub 2010 Jun 18.
9
Clinical results of primary malignant musculoskeletal tumor treated by wide resection and recycling autograft reconstruction using liquid nitrogen.采用液氮进行广泛切除及自体骨回植重建治疗原发性恶性肌肉骨骼肿瘤的临床结果
Asia Pac J Clin Oncol. 2015 Jun;11(2):114-20. doi: 10.1111/ajco.12197. Epub 2014 Jun 3.
10
Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.骨肉瘤患者接受肿瘤灭活冷冻自体移植后化疗组织学反应的预后价值。
PLoS One. 2013 Aug 15;8(8):e71362. doi: 10.1371/journal.pone.0071362. eCollection 2013.

引用本文的文献

1
Failure Modes in Orthopedic Oncologic Reconstructive Surgery: A Review of Imaging Findings and Failure Rates.骨科肿瘤重建外科中的失效模式：影像学发现与失效率的综述。
Curr Oncol. 2024 Oct 17;31(10):6245-6266. doi: 10.3390/curroncol31100465.
2
Complications and Outcome of Bone Sarcoma Patients with Limb Salvage using Liquid Nitrogen-treated Bone for Reconstruction.采用液氮处理骨重建保肢的骨肉瘤患者的并发症及结局
J Cancer Allied Spec. 2024 Jan 22;10(1):543. doi: 10.37029/jcas.v10i1.543. eCollection 2024.
3
A comparative study of reconstruction modalities after knee joint-preserving tumor resection: reconstruction with a custom-made endoprosthesis versus reconstruction with a liquid nitrogen-inactivated autologous bone graft.

本文引用的文献

1
The role of mechanical stimulation in the enhancement of bone healing.机械刺激在促进骨愈合中的作用。
Injury. 2021 Jun;52 Suppl 2:S78-S83. doi: 10.1016/j.injury.2020.10.009. Epub 2020 Oct 2.
2
Clinical course of grafted cartilage in osteoarticular frozen autografts for reconstruction after resection of malignant bone and soft-tissue tumor involving an epiphysis.用于涉及骨骺的恶性骨与软组织肿瘤切除术后重建的骨关节冷冻自体移植物中移植软骨的临床病程。
J Bone Oncol. 2020 Aug 2;24:100310. doi: 10.1016/j.jbo.2020.100310. eCollection 2020 Oct.
3
Risk Factors for Postoperative Deep Infection After Malignant Bone Tumor Surgery of the Extremities.
膝关节肿瘤切除术后重建方式的对比研究：定制假体重建与液氮灭活自体骨移植重建的比较。
J Orthop Surg Res. 2023 Nov 29;18(1):908. doi: 10.1186/s13018-023-04402-3.
4
Surgical Site Infection after Bone Tumor Surgery: Risk Factors and New Preventive Techniques.骨肿瘤手术后手术部位感染：危险因素与新的预防技术
Cancers (Basel). 2022 Sep 19;14(18):4527. doi: 10.3390/cancers14184527.
5
Hemiarthroplasty of Pedicle-Frozen Proximal Tibia for Primary Malignant Bone Tumours.带蒂冷冻胫骨近端半关节成形术治疗原发性恶性骨肿瘤
Indian J Orthop. 2022 May 30;56(7):1285-1290. doi: 10.1007/s43465-022-00658-9. eCollection 2022 Jul.
6
Joint-preservation surgery for bone sarcoma in adolescents and young adults.青少年和年轻成人骨肉瘤的保关节手术
Int J Clin Oncol. 2023 Jan;28(1):12-27. doi: 10.1007/s10147-022-02154-4. Epub 2022 Mar 26.
四肢恶性骨肿瘤手术后术后深部感染的危险因素。
Anticancer Res. 2020 Jun;40(6):3551-3557. doi: 10.21873/anticanres.14344.
4
Is frozen tumour-bearing autograft with concurrent vascularized fibula an alternative to the Capanna technique for the intercalary reconstruction after resection of osteosarcoma in the lower limb?冷冻肿瘤骨移植联合带血管腓骨移植是否可替代 Capanna 技术用于下肢骨肉瘤切除后节段性骨重建？
Bone Joint J. 2020 May;102-B(5):646-652. doi: 10.1302/0301-620X.102B5.BJJ-2019-1380.R1.
5
A long-term follow-up study of extracorporeal irradiated autografts in limb salvage surgery for malignant bone and soft tissue tumors: A minimum follow-up of 10 years after surgery.肢体恶性骨与软组织肿瘤保肢术后体外照射自体移植物的长期随访研究：术后至少 10 年的随访。
J Surg Oncol. 2020 Jun;121(8):1276-1282. doi: 10.1002/jso.25918. Epub 2020 Apr 4.
6
Do Massive Allograft Reconstructions for Tumors of the Femur and Tibia Survive 10 or More Years after Implantation?异体骨大段重建股骨和胫骨肿瘤，植入后 10 年以上存活率如何？
Clin Orthop Relat Res. 2020 Mar;478(3):517-524. doi: 10.1097/CORR.0000000000000806.
7
Joint-preservation surgery for pediatric osteosarcoma of the knee joint.膝关节儿童骨肉瘤的保关节手术。
Cancer Metastasis Rev. 2019 Dec;38(4):709-722. doi: 10.1007/s10555-019-09835-z.
8
Long-term outcomes of an extracorporeal irradiated autograft for limb salvage operations in musculoskeletal tumours: over ten years’ observation.肢体骨肉瘤保肢手术中体外辐照自体移植物的长期结果：超过十年的观察。
Bone Joint J. 2019 Sep;101-B(9):1151-1159. doi: 10.1302/0301-620X.101B9.BJJ-2019-0090.R1.
9
Advances in tumour endoprostheses: a systematic review.肿瘤内假体的进展：一项系统综述
EFORT Open Rev. 2019 Jul 2;4(7):445-459. doi: 10.1302/2058-5241.4.180081. eCollection 2019 Jul.
10
Bone morphogenetic protein activity preservation with extracorporeal irradiation- and liquid nitrogen freezing-treated recycled autografts for biological reconstruction in malignant bone tumor.体外照射和液氮冷冻处理再利用自体移植物保存骨形态发生蛋白活性，用于恶性骨肿瘤的生物重建。
Cryobiology. 2019 Aug;89:82-89. doi: 10.1016/j.cryobiol.2019.05.002. Epub 2019 May 5.