吡喹酮对日本血吸虫幼虫期的影响。

Effect of praziquantel on larval stages of Schistosoma japonicum.

作者信息

Yi X M, Combes C

机构信息

Chinese Academy of Preventive Medicine, Institute of Parasitic Diseases, Rui Fin Er Lu, Shanghai, People's Republic of China.

出版信息

Trans R Soc Trop Med Hyg. 1987;81(4):645-50. doi: 10.1016/0035-9203(87)90440-8.

DOI:10.1016/0035-9203(87)90440-8

PMID:3445349

Abstract

The effect of praziquantel on S. japonicum mother sporocysts, daughter sporocysts and cercariae was studied. At concentrations of 3 X 10(-7), 3 X 10(-6) and 3 X 10(-5) M and treatment times of 24 or 48 h, mother and daughter sporocysts and young cercarial embryos were not affected but nearly mature cercariae were killed and dissociated. The resistance of young cercariae could support the suggestion that the primitive cercarial epithelium arises from the sporocyst tegument. Treatment with praziquantel always stopped cercarial emission; this cessation lasted for a few days with the lowest concentration and for up to 25 d with the highest. The duration of treatment slightly affected the pattern of reappearance of cercariae but markedly affected the long-term reduction in numbers. Free cercariae treated with praziquantel lost their tails in 10 to 60 min, depending on the concentration.

摘要

研究了吡喹酮对日本血吸虫母胞蚴、子胞蚴和尾蚴的作用。在浓度为3×10⁻⁷、3×10⁻⁶和3×10⁻⁵M以及处理时间为24或48小时的情况下，母胞蚴、子胞蚴和幼尾蚴胚胎未受影响，但近成熟尾蚴被杀死并解体。幼尾蚴的抗性支持原始尾蚴上皮起源于胞蚴被膜的观点。吡喹酮处理总是会停止尾蚴逸出；这种停止在最低浓度下持续几天，在最高浓度下持续长达25天。处理持续时间对尾蚴再次出现的模式影响较小，但对数量的长期减少影响显著。用吡喹酮处理的游离尾蚴在10至60分钟内失去尾巴，具体时间取决于浓度。