Boston College, Connell School of Nursing, Chestnut Hill, MA, USA.
University of Kentucky, College of Nursing, 751 Rose Street, Lexington, KY 40356, USA.
Eur J Cardiovasc Nurs. 2022 Apr 9;21(3):254-260. doi: 10.1093/eurjcn/zvab070.
Left ventricular assist devices (LVAD) are used to treat advanced heart failure, and the use of these devices in ever increasing, with over 19 000 people having had a device. However, during device therapy over 50% of patients will have some type of major adverse event. The aim of this study was to examine whether having a major adverse event, including major infection and major bleed, would alter patient-reported outcomes over time, including depressive symptoms and health-related quality of life.
T-tests and χ2 analyses were used to determine significant differences between patients who had an adverse event and those who did not. Latent curve growth modelling was used to evaluate change over time in those patients with and without and adverse event. The only difference between those with and without an adverse event was pre-implant depressive symptoms and health-related quality of life. The trajectories of both groups were also similar, with only differences at the pre-implant time point.
In response to an adverse event occurring post-LVAD implantation, we found that patient-reported outcomes, including depressive symptoms and health-related quality of life were not significantly impacted.
左心室辅助装置（LVAD）用于治疗晚期心力衰竭，随着使用这些装置的人数不断增加，已有超过 19000 人使用了这些装置。然而，在装置治疗期间，超过 50%的患者会出现某种类型的重大不良事件。本研究旨在探讨重大不良事件（包括严重感染和严重出血）是否会随着时间的推移改变患者报告的结果，包括抑郁症状和健康相关生活质量。
采用 t 检验和 χ2 分析来确定发生不良事件和未发生不良事件的患者之间的显著差异。采用潜在曲线增长模型来评估有和无不良事件的患者随时间的变化。仅有不良事件发生前后的抑郁症状和健康相关生活质量存在差异。两组的轨迹也相似，仅在植入前时间点存在差异。
在 LVAD 植入后发生不良事件的情况下，我们发现患者报告的结果，包括抑郁症状和健康相关生活质量没有受到显著影响。
