School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed To Be University, Bhubaneswar, Odisha, 751024, India.
Mol Cell Biochem. 2021 Dec;476(12):4363-4385. doi: 10.1007/s11010-021-04249-4. Epub 2021 Aug 28.
Cervical cancer (CC) is one of the leading causes of death in women due to cancer and a major concern in the developing world. Persistent human papilloma virus (HPV) infection is the major causative agent for CC. Besides HPV infection, genetic and epigenetic factors including microRNA (miRNA) also contribute to the malignant transformation. Earlier studies have revealed that miRNAs participate in cell proliferation, invasion and metastasis, angiogenesis, and chemoresistance processes by binding and inversely regulating the target oncogenes or tumor suppressor genes. Based on functions and mechanistic insights, miRNAs have been identified as cellular modulators that have an enormous role in diagnosis, prognosis, and cancer therapy. Signatures of miRNA could be used as diagnostic markers which are necessary for early diagnosis and management of CC. The therapeutic potential of miRNAs has been shown in CC; however, more comprehensive clinical trials are required for the clinical translation of miRNA-based diagnostics and therapeutics. Understanding the molecular mechanism of miRNAs and their target genes has been useful to develop miRNA-based therapeutic strategies for CC and overcome chemoresistance. In this review, we summarize the role of miRNAs in the development, progression, and metastasis of CC as well as chemoresistance. Further, we discuss the diagnostic and therapeutic potential of miRNAs to overcome chemoresistance and treatment of CC.
宫颈癌（CC）是癌症导致女性死亡的主要原因之一，也是发展中国家的主要关注点。持续性人乳头瘤病毒（HPV）感染是 CC 的主要致病因素。除 HPV 感染外，遗传和表观遗传因素，包括 microRNA（miRNA），也有助于恶性转化。早期研究表明，miRNA 通过结合并反向调节靶原癌基因或肿瘤抑制基因，参与细胞增殖、侵袭和转移、血管生成和化疗耐药过程。基于功能和机制的见解，miRNA 已被确定为细胞调节剂，在诊断、预后和癌症治疗中具有重要作用。miRNA 的特征可以用作诊断标志物，这对于 CC 的早期诊断和管理是必要的。miRNA 在 CC 中的治疗潜力已经得到证实；然而，需要更多全面的临床试验来将 miRNA 为基础的诊断和治疗方法进行临床转化。了解 miRNA 及其靶基因的分子机制有助于开发基于 miRNA 的 CC 治疗策略并克服化疗耐药性。在这篇综述中，我们总结了 miRNA 在 CC 的发展、进展和转移以及化疗耐药性中的作用。此外，我们讨论了 miRNA 在克服化疗耐药性和治疗 CC 方面的诊断和治疗潜力。
