School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
Adv Exp Med Biol. 2021;1288:95-109. doi: 10.1007/978-3-030-77779-1_5.
Coxsackievirus and adenovirus receptor (CXADR) belongs to immunoglobulin superfamily of cell adhesion molecules. It expresses in most tissues, but displays unique and indispensable functions in some tissues such as heart and testis. CXADR is a multifunctional protein that can serve as a viral receptor, a junction structural protein and a signalling molecule. Thus, it exerts a wide range of functions such as facilitating leukocyte transmigration, regulating barrier function and cell adhesion, promoting EMT transition, and mediating spermatogenesis. This review aims to provide an overview and highlights some recent findings on CXADR in the field with emphasis on studies in the testis, upon which future studies can be designed to delineate the roles and regulation of CXADR in spermatogenesis.
柯萨奇病毒和腺病毒受体（CXADR）属于细胞黏附分子免疫球蛋白超家族。它在大多数组织中表达，但在某些组织中具有独特且不可或缺的功能，如心脏和睾丸。CXADR 是一种多功能蛋白，可作为病毒受体、连接结构蛋白和信号分子。因此，它发挥了广泛的功能，如促进白细胞迁移、调节屏障功能和细胞黏附、促进 EMT 转化以及介导精子发生。本综述旨在概述 CXADR 在该领域的最新研究进展，并重点介绍睾丸方面的研究，为未来研究设计提供依据，以阐明 CXADR 在精子发生中的作用和调节机制。
