Ignatov G, Belchev L, Ignatova M, Tunkara A, Arnaudov D
Vet Med Nauki. 1987;24(9):22-30.
Studied were the pathohistological changes and the morphologic-structural injuries of intestinal mucosa of pigs (5-7 days old), spontaneously affected with rotavirus diarrhea, raised by traditional methods. Simultaneously with the rotavirus invasion was established Isospora suis. In spite of the early time of the disorder (the test was carried out 24 hours after the appearance of the first clinical symptoms) there were established different in degree and expression morphologic changes; atrophy and fusion of the fibrils, replacement of the cylindrical epithelium with cubic, dystrophy and exfoliation of the enterocytes with exposure of the lamina propria. The burden of the dystrophic processes, which has affected the intestinal mycosis, was registered by scanning electronic microscopy. The dystrophic processes start at the top of the intestinal fibrils, the fusion of the fibrils spreads over a big number of them, forming a conglomerate mass. Simultaneously with the fibrils, affected by dystrophy, were observed fibrils with normal shape and size. During immunofluorescent examinations also is observed focal distribution of enterocytes, containing antigen on some of the fibrils. Now is discussed the importance of the pathogenic microflora, in the intestinal track of pigs, raised by traditional methods, for the early appearance and for the burden of the morphologic-structural changes.
对采用传统方法饲养的5至7日龄自然感染轮状病毒腹泻的仔猪肠道黏膜的病理组织学变化和形态结构损伤进行了研究。与轮状病毒感染同时发现了猪等孢球虫。尽管发病时间较早（在首次出现临床症状24小时后进行检测），但仍发现了程度和表现各异的形态学变化；纤毛萎缩和融合，柱状上皮被立方上皮取代，肠细胞营养不良和脱落，固有层暴露。通过扫描电子显微镜记录了影响肠道霉菌病的营养不良过程的严重程度。营养不良过程始于肠纤毛顶部，纤毛融合扩散到大量纤毛，形成聚集体。在出现营养不良的纤毛的同时，还观察到形状和大小正常的纤毛。在免疫荧光检查中，还观察到部分纤毛上含有抗原的肠细胞呈局灶性分布。目前正在讨论传统饲养方式下猪肠道中致病微生物群对于形态结构变化的早期出现和严重程度的重要性。
