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降低孕产妇死亡率:需要将行动重点放在预防妊娠高血压疾病上。

Maternal mortality reduction: a need to focus actions on the prevention of hypertensive disorders of pregnancy.

机构信息

Centro de Investigaciones Epidemiológicas y Salud Pública (CIESP-IECS), CONICET, 1414, Ciudad de Buenos Aires, Argentina.

Department of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS-CONICET), 1414, Ciudad de Buenos Aires, Argentina.

出版信息

Int J Equity Health. 2021 Aug 28;20(1):194. doi: 10.1186/s12939-021-01535-x.

Abstract

Maternal mortality (MM) reflects one of the most striking global health inequalities. Global figures of MM fell significantly from 1990 to 2017. The reduction was largely due to a 70% fall in haemorrhages, and a limited (18.2%) improvement in hypertensive disorders of pregnancy (HDP). If this trend continues, by 2021 HDP will be the main cause of global MM.MM reductions due to haemorrhage is reassuring, however MM due to HDP show a more complex situation as early detection of HDP requires regular contact of pregnant women with the health system. In order to reduce MM due to HDP, population wide preventive actions such as low dose aspirin and adequate calcium intake are required, especially in areas where women have little contact with the health systems.Calcium supplementation for women with low calcium intake has reduced the risk of pre-eclampsia, with further reductions starting daily supplementation with 500 mg of calcium preconceptionally, however adherence to supplementation is limited.To reduce global inequities in calcium intake and consequently in the HDP, food fortification seem to be an attractive strategy to achieve an increase of calcium intake.

摘要

孕产妇死亡率(MM)反映了全球最显著的健康不平等现象之一。全球孕产妇死亡率从 1990 年到 2017 年显著下降。这一降幅主要归因于出血减少了 70%,以及妊娠高血压疾病(HDP)的改善有限(18.2%)。如果这一趋势持续下去,到 2021 年,HDP 将成为全球 MM 的主要原因。出血导致的 MM 减少令人欣慰,但由于 HDP 导致的 MM 情况更为复杂,因为早期发现 HDP 需要孕妇与卫生系统保持定期联系。为了降低 HDP 导致的 MM,需要采取人群预防措施,如低剂量阿司匹林和充足的钙摄入,特别是在妇女与卫生系统接触较少的地区。对于钙摄入量低的妇女,补充钙可降低子痫前期的风险,每天补充 500 毫克钙可进一步降低风险,但补充剂的依从性有限。为了减少全球钙摄入量和 HDP 的不平等,食品强化似乎是增加钙摄入量的一种有吸引力的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02c9/8403409/8e5dadb3426a/12939_2021_1535_Fig1_HTML.jpg

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