Tang Zhongyun, Ma Chao, Liu Jin, Liu Chongdong
Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Clinical Medical College, Hebei University, Baoding, Hebei, China.
Front Glob Womens Health. 2025 May 9;6:1533843. doi: 10.3389/fgwh.2025.1533843. eCollection 2025.
Hypertensive disorders of pregnancy (HDP) are a significant cause of maternal and perinatal morbidity and mortality worldwide. This study aims to use the Global Burden of Disease 2021 database to analyze the prevalence trends and disease burden of HDP across the globe from 2019 to 2021.
We analyzed four key metrics related to HDP (prevalence, incidence, mortality, and DALYs) using data from the GBD Database. Trends were assessed using the estimated annual percentage change (EAPC) and changes in disease burden.
In 2021, global HDP prevalence cases, incidence cases, mortality cases, and DALYs were 3.51 million, 18.00 million, 37.58 million, and 2.44 million, respectively, with percentage changes of 14%, 15%, -29%, and -29% over the study period. Prevalence and incidence rates increased (EAPCs: -0.7 and -0.67), while mortality and DALYs rates decreased (EAPCs: -2.29 and -2.28). Low Socio-demographic Index (SDI) regions had the highest HDP burden, accounting for about half of the global total. The 25-29 age group had the highest incidence cases.
Over the past 32 years, HDP prevalence cases and incidence cases have risen globally, but death cases and DALYs cases have significantly decreased, particularly in low SDI regions and the 25-29 age group. The global HDP burden is higher in regions with lower SDI. Our findings highlight regional and age-related disparities in HDP, providing a basis for targeted interventions and prevention strategies.
妊娠期高血压疾病（HDP）是全球孕产妇和围产期发病及死亡的重要原因。本研究旨在利用2021年全球疾病负担数据库分析2019年至2021年全球范围内HDP的患病率趋势和疾病负担。
我们使用全球疾病负担（GBD）数据库的数据，分析了与HDP相关的四个关键指标（患病率、发病率、死亡率和伤残调整生命年）。使用估计年百分比变化（EAPC）和疾病负担变化评估趋势。
2021年，全球HDP患病率病例、发病率病例、死亡病例和伤残调整生命年分别为351万、1800万、375.8万和244万，在研究期间百分比变化分别为14%、15%、-29%和-29%。患病率和发病率上升（EAPC分别为-0.7和-0.67），而死亡率和伤残调整生命年率下降（EAPC分别为-2.29和-2.28）。社会人口指数（SDI）较低的地区HDP负担最高，约占全球总数的一半。25-29岁年龄组的发病率病例最高。
在过去32年中，全球HDP患病率病例和发病率病例有所上升，但死亡病例和伤残调整生命年病例显著下降，特别是在低SDI地区和25-29岁年龄组。SDI较低地区的全球HDP负担更高。我们的研究结果突出了HDP在区域和年龄方面的差异，为有针对性的干预措施和预防策略提供了依据。
