Morphofunctional Study and Research Group in Health and Disease, Universidade Federal de Jataí, Jataí, Goiás, Brazil.
Postgraduate Program in Applied Health Sciences, Universidade Federal de Jataí, Jataí, Goiás, Brazil.
Curr HIV Res. 2024;22(4):213-218. doi: 10.2174/011570162X306973240802104449.
HIV infection is a worldwide epidemic. Antiretroviral therapy allows people living with HIV (PLHIV) increased longevity and a better quality of life. Among the various ways of monitoring the clinical evolution of PLHIV, handgrip strength (HGS) is a promising strategy, as this test can be used to assess the health condition quickly and at a low cost. In this sense, the present study aims to describe, through a literature review, the relationship between HGS and the clinical evolution of PLHIV, especially with morbimortality. Initially, it is highlighted that aging, HIV infection, and excess body fat are related to the loss of HGS in PLHIV. Furthermore, PLHIV is more likely to present cardiometabolic diseases that can be aggravated by reduced HGS. Thus, in people without positive HIV serology, low HGS indirectly, through the presence of risk factors or cardiometabolic diseases, or directly increases the chance of mortality. In conclusion, the lack of studies on this topic for PLHIV is highlighted, and more longitudinal studies, including control groups, are needed.
HIV 感染是一种全球性的流行病。抗逆转录病毒疗法使 HIV 感染者（PLHIV）的寿命延长，生活质量提高。在监测 PLHIV 临床进展的各种方法中，握力（HGS）是一种很有前途的策略，因为这项测试可以快速、低成本地评估健康状况。从这个意义上说，本研究旨在通过文献回顾描述 HGS 与 PLHIV 临床进展的关系，特别是与发病率和死亡率的关系。首先，值得强调的是，衰老、HIV 感染和体脂过多与 PLHIV 握力下降有关。此外，PLHIV 更容易出现心血管代谢疾病，而握力下降会使这些疾病恶化。因此，在没有 HIV 血清学阳性的人群中，通过存在危险因素或心血管代谢疾病，间接导致握力下降，或直接导致死亡率增加。总之，PLHIV 人群中缺乏关于这个主题的研究，需要进行更多的包括对照组在内的纵向研究。
