Nove de Julho University, Sao Paulo-SP, Brazil.
Physical Education Department, Rural Federal University of Pernambuco, Recife-PE, Brazil.; Graduate Program in Physical Education, Federal University of Pernambuco (UFPE), Recife, Brazil.
Ann Vasc Surg. 2021 Nov;77:31-37. doi: 10.1016/j.avsg.2021.06.011. Epub 2021 Aug 26.
The mechanisms underlying functional impairments in symptomatic PAD patients are controversial and poorly understood. Endothelial dysfunction and arterial stiffness have been proposed as potential mechanisms related to functional impairment in symptomatic PAD patients, however, more studies are needed to confirm these associations.
To analyze the association between vascular function and walking impairment in patients with peripheral arterial disease (PAD) and symptoms of claudication.
This was a cross-sectional study that included 68 patients with symptomatic PAD. All patients underwent an objective (Six-minute walk test [6MWT], 4-meter walk test) and a subjective (Walking Impairment Questionnaire [WIQ]) measurement of walking impairment. Vascular parameters measured were pulse-wave velocity (PWV) and flow-mediated dilation (FMD). Multiple linear regression was performed to investigate the association among walking impairment variables with vascular function parameters.
No significant associations between the claudication onset distance (PWV: b=.060, P = 0.842; FMD: b=-.192, P = 0.456), 6MWT (PWV: b=.007, P = 0..975; FMD: b=.090, P = 0.725), WIQ distance (PWV: b=.337, P = 0.117; FMD: b=-.025, P = 0.895) WIQ speed (PWV: b=.320, P = 0.181; FMD: b=-.028, P = 0.497), WIQ stairs (PWV: b=.256, P = 0.204; FMD: b=-.228, P = 0.230), 4-meter usual walk (PWV: b=-.421, P = 0.107; FMD: b=-.338, P = 0.112), 4-meter fast walk (PWV: b=-.496, P = 0.063; FMD: b=-.371, P = 0.086) and vascular function were found.
In symptomatic PAD patients, vascular function is not associated to walking impairment, even when adjusting for comorbid conditions and diabetes.
有症状的 PAD 患者的功能障碍的机制尚存在争议，目前了解甚少。内皮功能障碍和动脉僵硬度被认为与有症状的 PAD 患者的功能障碍有关，但仍需要更多的研究来证实这些关联。
分析外周动脉疾病（PAD）和跛行症状患者的血管功能与步行障碍之间的关系。
这是一项横断面研究，纳入了 68 例有症状的 PAD 患者。所有患者均进行了客观（6 分钟步行试验[6MWT]、4 米步行试验）和主观（步行障碍问卷[WIQ]）步行障碍测量。测量的血管参数包括脉搏波速度（PWV）和血流介导的舒张（FMD）。采用多元线性回归分析步行障碍变量与血管功能参数之间的关系。
跛行起始距离与 PWV（b=0.060，P=0.842）和 FMD（b=-0.192，P=0.456）之间无显著相关性，6MWT 与 PWV（b=0.007，P=0.975）和 FMD（b=0.090，P=0.725）之间也无显著相关性，WIQ 距离与 PWV（b=0.337，P=0.117）和 FMD（b=-0.025，P=0.895）之间无显著相关性，WIQ 速度与 PWV（b=0.320，P=0.181）和 FMD（b=-0.028，P=0.497）之间也无显著相关性，WIQ 爬楼梯与 PWV（b=0.256，P=0.204）和 FMD（b=-0.228，P=0.230）之间也无显著相关性，4 米常规步行与 PWV（b=-0.421，P=0.112）和 FMD（b=-0.338，P=0.112）之间也无显著相关性，4 米快速步行与 PWV（b=-0.496，P=0.063）和 FMD（b=-0.371，P=0.086）之间也无显著相关性。
在有症状的 PAD 患者中，血管功能与步行障碍无关，即使在调整了合并症和糖尿病等因素后也是如此。
