Davletov E G, Saliakhova R M, Kamilov F Kh
Vopr Med Khim. 1987 Nov-Dec;33(6):51-6.
Impairments of protein metabolism, expressed as predominance of catabolism over anabolism and hypoproteinemia, were observed in one month old rats with experimental burns of the IIIA-IIIB degree, when 20-25% of a body surface was impaired. After administration of steroid drugs (retabolyl at a dose of 1 mg/100 g of body mass or oxymetacyl--4-methyl-5-oxyuracil---at a dose of 5 mg/100 g of body mass) content of protein and urea normalized in blood serum, activity of cathepsin D decreased in tissues, the rate of 35S-methionine incorporation into tissue proteins increased. The pyrimidine derivative oxymetacyl exhibited higher effect on protein metabolism in burns of preadolescent rats as compared with retabolyl.
在体表面积20 - 25%受到损伤的III A - III B度实验性烧伤的1月龄大鼠中，观察到蛋白质代谢受损，表现为分解代谢超过合成代谢以及低蛋白血症。给予类固醇药物（维丙胺，剂量为1毫克/100克体重；或氧甲嘧啶——4 - 甲基 - 5 - 氧尿嘧啶——剂量为5毫克/100克体重）后，血清中蛋白质和尿素含量恢复正常，组织中组织蛋白酶D的活性降低，35S - 蛋氨酸掺入组织蛋白的速率增加。与维丙胺相比，嘧啶衍生物氧甲嘧啶对青春期前大鼠烧伤时的蛋白质代谢表现出更高的作用效果。
