Matiushin I F, Boiarinov G A, Bogdarin Iu A
Vopr Med Khim. 1981 Sep-Oct;27(5):604-7.
Metabolism of fatty acids in rat liver tissue and content of albumin in blood of control rats as well as in the animals with impaired protein metabolism as a result of thermic trauma were studied under conditions of nerobolyl treatment (5 mg per kg of body mass within a day) of different duration. After daily administration of the drug (within 13 days) into control rats and into the animals with burns, content of oleic and linoleic acids was decreased in liver tissue but the content of 5,8,11-eicosatrienic acid and total monoenic acids with uneven amount of carbon atoms was increased with simultaneous decrease in albumin concentration in blood. Metabolism of fatty acids was altered only slightly in liver tissue of healthy animals after nerobolyl administration within three weeks (with an interval for 3-4 days); under conditions of the thermic trauma nerobolyl normalized the fatty acids metabolism in liver tissue and increased the albumin content in blood.
在不同时长的奈若渤治疗（每日每千克体重5毫克）条件下，研究了正常大鼠以及因热创伤导致蛋白质代谢受损的动物的大鼠肝脏组织中脂肪酸的代谢情况以及血液中白蛋白的含量。在对正常大鼠和烧伤动物每日给药（持续13天）后，肝脏组织中油酸和亚油酸的含量降低，但5,8,11-二十碳三烯酸和具有奇数碳原子的总单烯酸的含量增加，同时血液中白蛋白浓度降低。在健康动物肝脏组织中，连续三周（间隔3 - 4天）给予奈若渤后，脂肪酸代谢仅有轻微改变；在热创伤条件下，奈若渤使肝脏组织中的脂肪酸代谢正常化，并增加了血液中白蛋白的含量。
