• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
PNPLA3 and COVID-19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system.PNPLA3与新冠病毒感染的结果：跳出框框思考或许能解释rs738409对免疫系统多效性作用背后的生物学机制。
Liver Int. 2021 Nov;41(11):2801-2804. doi: 10.1111/liv.15043. Epub 2021 Sep 6.
2
A common variant in PNPLA3 is associated with age at diagnosis of NAFLD in patients from a multi-ethnic biobank.一种常见的 PNPLA3 变异与多民族生物库中 NAFLD 患者的诊断年龄相关。
J Hepatol. 2020 Jun;72(6):1070-1081. doi: 10.1016/j.jhep.2020.01.029. Epub 2020 Mar 5.
3
Association of metabolic syndrome and patatin-like phospholipase 3 - rs738409 gene variant in non-alcoholic fatty liver disease among a Chennai-based south Indian population.基于印度钦奈的南印度人群的研究发现，代谢综合征与 patatin 样磷脂酶 3-rs738409 基因变异与非酒精性脂肪性肝病相关。
J Gene Med. 2020 Apr;22(4):e3160. doi: 10.1002/jgm.3160. Epub 2020 Feb 3.
4
Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis.载脂蛋白基因多态性与儿童非酒精性脂肪性肝病的关系: 荟萃分析。
BMC Med Genet. 2020 Aug 18;21(1):163. doi: 10.1186/s12881-020-01098-8.
5
A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children.载脂蛋白基因中的一个常见变异是台湾肥胖儿童非酒精性脂肪肝的一个危险因素。
J Pediatr. 2011 May;158(5):740-4. doi: 10.1016/j.jpeds.2010.11.016. Epub 2010 Dec 18.
6
The PNPLA3 rs738409 GG genotype is associated with poorer prognosis in 239 patients with autoimmune hepatitis.载脂蛋白基因多态性与自身免疫性肝炎 239 例患者的预后不良相关。
Aliment Pharmacol Ther. 2020 Jun;51(11):1160-1168. doi: 10.1111/apt.15722. Epub 2020 Apr 22.
7
[Polymorphism rs738409 in PNPLA3 is associated with inherited susceptibility to non-alcoholic fatty liver disease].PNPLA3基因中的rs738409多态性与非酒精性脂肪性肝病的遗传易感性相关
Zhonghua Gan Zang Bing Za Zhi. 2013 Aug;21(8):619-23. doi: 10.3760/cma.j.issn.1007-3418.2013.08.013.
8
PNPLA3 gene polymorphism and overall and cardiovascular mortality in the United States.PNPLA3 基因多态性与美国的全因和心血管死亡率。
J Gastroenterol Hepatol. 2020 Oct;35(10):1789-1794. doi: 10.1111/jgh.15045. Epub 2020 Apr 12.
9
PNPLA3 rs738409 is associated with renal glomerular and tubular injury in NAFLD patients with persistently normal ALT levels.载脂蛋白 L3 基因 rs738409 多态性与持续正常丙氨酸氨基转移酶水平的非酒精性脂肪性肝病患者的肾肾小球和肾小管损伤相关。
Liver Int. 2020 Jan;40(1):107-119. doi: 10.1111/liv.14251. Epub 2019 Oct 7.
10
Role of the PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in Korea.PNPLA3 I148M基因多态性在韩国非酒精性脂肪性肝病和肝纤维化中的作用
Dig Dis Sci. 2014 Dec;59(12):2967-74. doi: 10.1007/s10620-014-3279-z. Epub 2014 Jul 29.

引用本文的文献

1
Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.PNPLA3 I148M对肝脏疾病的全球流行病学影响。
Liver Int. 2025 Mar;45(3):e16123. doi: 10.1111/liv.16123. Epub 2024 Oct 7.
2
The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants.冠状病毒病-19发病机制的多效性研究方法：肝脏疾病相关宿主基因变异的影响
Hepatol Forum. 2023 Dec 7;5(2):93-96. doi: 10.14744/hf.2023.2023.0018. eCollection 2024.
3
Personalized medicine in nonalcoholic fatty liver disease.非酒精性脂肪性肝病中的个性化医疗
Clin Mol Hepatol. 2022 Oct;28(4):935-938. doi: 10.3350/cmh.2022.0175. Epub 2022 Jun 24.

本文引用的文献

1
PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19.PNPLA3和TLL-1基因多态性作为COVID-19患者疾病严重程度的潜在预测指标
Front Cell Dev Biol. 2021 Jun 23;9:627914. doi: 10.3389/fcell.2021.627914. eCollection 2021.
2
COVID-19 and liver disease: mechanistic and clinical perspectives.COVID-19 与肝病：机制与临床视角。
Nat Rev Gastroenterol Hepatol. 2021 May;18(5):348-364. doi: 10.1038/s41575-021-00426-4. Epub 2021 Mar 10.
3
The rs738409 G Allele in PNPLA3 Is Associated With a Reduced Risk of COVID-19 Mortality and Hospitalization.PNPLA3基因中的rs738409 G等位基因与降低COVID-19死亡和住院风险相关。
Gastroenterology. 2021 Jun;160(7):2599-2601.e2. doi: 10.1053/j.gastro.2021.02.059. Epub 2021 Feb 27.
4
Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system.与非酒精性脂肪性肝病及造血系统特征相关的基因变异中的多效性。
World J Gastroenterol. 2021 Jan 28;27(4):305-320. doi: 10.3748/wjg.v27.i4.305.
5
Genetic insight into COVID-19-related liver injury.对新型冠状病毒肺炎相关肝损伤的遗传学见解。
Liver Int. 2021 Jan;41(1):227-229. doi: 10.1111/liv.14708. Epub 2020 Nov 3.
6
Lack of genetic evidence that fatty liver disease predisposes to COVID-19.缺乏脂肪肝疾病易引发2019冠状病毒病的基因证据。
J Hepatol. 2020 Sep;73(3):709-711. doi: 10.1016/j.jhep.2020.05.015. Epub 2020 May 20.
7
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.血小板减少症与严重的 2019 年冠状病毒病（COVID-19）感染相关：一项荟萃分析。
Clin Chim Acta. 2020 Jul;506:145-148. doi: 10.1016/j.cca.2020.03.022. Epub 2020 Mar 13.
8
Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology.非酒精性脂肪性肝病的遗传途径：系统生物学的见解。
Hepatology. 2020 Jul;72(1):330-346. doi: 10.1002/hep.31229.
9
Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.用反义寡核苷酸沉默 Pnpla3 可改善 Pnpla3 I148M 敲入小鼠的非酒精性脂肪性肝炎和肝纤维化。
Mol Metab. 2019 Apr;22:49-61. doi: 10.1016/j.molmet.2019.01.013. Epub 2019 Feb 5.
10
Phenome-wide association studies across large population cohorts support drug target validation.全表型关联研究在大型人群队列中支持药物靶点验证。
Nat Commun. 2018 Oct 16;9(1):4285. doi: 10.1038/s41467-018-06540-3.

PNPLA3 and COVID-19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system.

作者信息

Pirola Carlos J, Sookoian Silvia

机构信息

School of Medicine, Institute of Medical Research A Lanari, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Department of Molecular Genetics and Biology of Complex Diseases, National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Institute of Medical Research (IDIM), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

出版信息

Liver Int. 2021 Nov;41(11):2801-2804. doi: 10.1111/liv.15043. Epub 2021 Sep 6.

DOI:10.1111/liv.15043
PMID:34455682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8662082/
Abstract
摘要