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可乐定治疗糖尿病性肠病腹泻

[Therapy of diarrhea in diabetic enteropathy with clonidine].

作者信息

Bretzke G

机构信息

II. Medizinischen Klinik, Bezirkskrankenhauses Heinrich Braun Zwickau.

出版信息

Z Gesamte Inn Med. 1987 Dec 1;42(23):680-2.

PMID:3445652
Abstract

The syndrome of neuropathy belongs to the frequent complications of diabetes. Within a visceral neuropathy a diabetic enteropathy may appear, in which cases diarrhoeas and incontinence stand to the fore. The therapy of the symptoms and signs is often difficult. It is reported on the influence by means of the antihypertensive drug clonidin (Haemiton). In 4 out of 9 patients a regression of the frequency of motion from on an average 8 to 2 a day took place. 2 other patients examined reported on an improvement. Also the nocturnal incontinence could positively be influenced. The antidiarrhoeic effect of clonidin is perhaps based on a direct stimulation of alpha 2-receptors.

摘要

神经病变综合征属于糖尿病常见并发症。在内脏神经病变中,可能会出现糖尿病性肠病,这种情况下腹泻和大小便失禁较为突出。症状和体征的治疗往往很困难。本文报道了抗高血压药物可乐定(海米托)的影响。9名患者中有4名患者的排便次数从平均每天8次降至2次。另外2名接受检查的患者报告病情有所改善。夜间大小便失禁也得到了积极改善。可乐定的止泻作用可能基于对α2受体的直接刺激。

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