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扶正和肤止痒方改善银屑病模型中Akt/mTORC1/S6K1信号通路对表皮分化的抑制作用。

Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models.

作者信息

Lu Yue, Chen Haiming, Zhang Junhong, Tang Bin, Zhang Hongyu, Ma Changju, Tang Xiaojuan, Li Li, Wu Jingjing, Wei Jianan, Li Shaoping, Yang Lei, Han Ling, Lu Chuanjian

机构信息

State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China.

Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, China.

出版信息

Front Pharmacol. 2021 Aug 11;12:650816. doi: 10.3389/fphar.2021.650816. eCollection 2021.

DOI:10.3389/fphar.2021.650816
PMID:34456715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8386017/
Abstract

Psoriasis is a chronic proliferative skin disorder characterised by abnormal epidermal differentiation. The Fuzhenghefuzhiyang (FZHFZY) formula created by Chuanjian Lu, a master of Chinese medicine in dermatology, has been external used in the Guangdong Provincial Hospital of Chinese Medicine for the treatment of psoriasis, but its mechanisms of action against psoriasis remain poorly understood. This study involved an exploration of the effects of FZHFZY on epidermal differentiation and its underlying mechanisms in interleukin (IL)-17A/IL-22/interferon (IFN)-γ/tumour necrosis factor (TNF)-α-stimulated HaCaT cells and in a mouse model of imiquimod (IMQ)-induced psoriasis. Cell viability was assessed by MTT assay. Epidermal differentiation was detected by reverse-transcription polymerase chain reaction and western blotting. Histological evaluation of the skin tissue was performed haematoxylin and eosin staining, and the Akt/mTORC1/S6K1 pathway was analysed by western blotting. FZHFZY inhibited proliferation and improved epidermal differentiation in IL-17A/IL-22/IFN-γ/TNF-α-induced HaCaT cells. FZHFZY ameliorated symptoms of psoriasis, regulated epidermal differentiation and inhibited phosphorylation of the Akt/mTORC1/S6K1 pathway in the skin of mice with imiquimod-induced psoriasis. Our results suggest that FZHFZY may exhibit therapeutic action against psoriasis by regulating epidermal differentiation inhibition of the Akt/mTORC1/S6K1 pathway.

摘要

银屑病是一种以表皮分化异常为特征的慢性增殖性皮肤病。由中医皮肤科大师卢传坚创制的扶正和肤止痒方（FZHFZY）已在广东省中医院外用治疗银屑病，但其治疗银屑病的作用机制尚不清楚。本研究探讨了扶正和肤止痒方对白细胞介素（IL）-17A/白细胞介素-22/干扰素（IFN）-γ/肿瘤坏死因子（TNF）-α刺激的HaCaT细胞以及咪喹莫特（IMQ）诱导的银屑病小鼠模型中表皮分化的影响及其潜在机制。通过MTT法评估细胞活力。通过逆转录聚合酶链反应和蛋白质印迹法检测表皮分化。对皮肤组织进行苏木精和伊红染色进行组织学评估，并通过蛋白质印迹法分析Akt/mTORC1/S6K1信号通路。扶正和肤止痒方抑制IL-17A/IL-22/IFN-γ/TNF-α诱导的HaCaT细胞增殖并改善表皮分化。扶正和肤止痒方改善了银屑病症状，调节了表皮分化，并抑制了咪喹莫特诱导的银屑病小鼠皮肤中Akt/mTORC1/S6K1信号通路的磷酸化。我们的结果表明，扶正和肤止痒方可能通过调节表皮分化和抑制Akt/mTORC1/S6K1信号通路对银屑病发挥治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8386017/60f7a7dc07db/fphar-12-650816-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8386017/41169d559276/fphar-12-650816-g001.jpg
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