Eleftheriou Maria Eleni, Thomas Emily
Department of Clinical Psychopharmacology, University College London, London, United Kingdom.
Front Psychiatry. 2021 Aug 11;12:707057. doi: 10.3389/fpsyt.2021.707057. eCollection 2021.
Mindfulness-based interventions and psychedelic-assisted therapy have been experimentally utilised in recent years as alternative treatments for various psychopathologies with moderate to great success. Both have also demonstrated significant post-acute and long-term decreases in clinical symptoms and enhancements in well-being in healthy participants. These two therapeutic interventions share various postulated salutogenic mechanisms, such as the ability to alter present-moment awareness and anti-depressive action, corresponding neuromodulatory effects. Recent preliminary evidence has also demonstrated that psychedelic administration can enhance mindfulness capacities which has already been demonstrated robustly as a result of mindfulness-based interventions. These shared mechanisms between mindfulness-based interventions and psychedelic therapy have led to scientists theorising, and recently demonstrating, synergistic effects when both are used in combination, in the form of potentiated therapeutic benefit. These synergistic results hold great promise but require replication in bigger sample groups and better controlled methodologies, to fully delineate the effect of set and setting, before they can be extended onto clinical populations.
近年来，基于正念的干预措施和迷幻辅助疗法已被用于实验，作为治疗各种精神病理学的替代疗法，并取得了中度到巨大的成功。两者还都显示出健康参与者的临床症状在急性发作后和长期显著减轻，幸福感增强。这两种治疗干预措施有各种假定的健康促进机制，例如改变当下意识的能力和抗抑郁作用，以及相应的神经调节作用。最近的初步证据还表明，迷幻药物的使用可以增强正念能力，而基于正念的干预措施已经有力地证明了这种能力。基于正念的干预措施和迷幻疗法之间的这些共同机制，导致科学家们进行理论推测，并且最近证明，当两者结合使用时会产生协同效应，表现为增强的治疗效果。这些协同结果前景广阔，但需要在更大的样本组中进行重复，并采用更好的对照方法，以充分阐明环境和背景的影响，然后才能推广到临床人群。
