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是否维持或加强对坏疽性脓皮病溃疡型的治疗可能取决于两到四周治疗干预后的反应：三例详细临床病程的结果。

Whether to maintain or strengthen the treatment for pyoderma gangrenosum ulcerative type may depend on the response after two to four-week treatment intervention: The outcome of three cases with details clinical course.

作者信息

Nakayama Yuichi, Akeda Tomoko, Iida Shohei, Habe Koji, Yokota Naho, Matsushima Yoshiaki, Nakai Yasuo, Kondo Makoto, Yamanaka Keiichi

机构信息

Department of Dermatology Mie University Graduate School of Medicine Tsu Japan.

出版信息

Clin Case Rep. 2021 Aug 21;9(8):e04690. doi: 10.1002/ccr3.4690. eCollection 2021 Aug.

DOI:10.1002/ccr3.4690
PMID:34457299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8380082/
Abstract

Determining whether the treatment intensity needs to be increased or can be maintained at a constant level may be suggested after 2-4 weeks of treatment. The use of TNF-α inhibitor, removal of necrotic tissue, and skin grafting may promote epithelialization.

摘要

治疗2 - 4周后，可能建议确定治疗强度是否需要增加或维持在恒定水平。使用肿瘤坏死因子-α抑制剂、清除坏死组织和皮肤移植可能促进上皮形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/b37cac2f17b3/CCR3-9-e04690-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/25a35cf90794/CCR3-9-e04690-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/cdd6315fb0c5/CCR3-9-e04690-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/b37cac2f17b3/CCR3-9-e04690-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/25a35cf90794/CCR3-9-e04690-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/cdd6315fb0c5/CCR3-9-e04690-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2995/8380082/b37cac2f17b3/CCR3-9-e04690-g003.jpg

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本文引用的文献

1
Adalimumab in Japanese patients with active ulcers of pyoderma gangrenosum: Twenty-six-week phase 3 open-label study.阿达木单抗治疗日本坏疽性脓皮病活动性溃疡患者：26周3期开放标签研究。
J Dermatol. 2020 Dec;47(12):1383-1390. doi: 10.1111/1346-8138.15533. Epub 2020 Aug 17.
2
Epidemiology of pyoderma gangrenosum in Japanese patients by questionnaire survey.通过问卷调查对日本患者坏疽性脓皮病的流行病学研究
J Dermatol. 2019 Apr;46(4):e145-e146. doi: 10.1111/1346-8138.14658. Epub 2018 Sep 19.
3
Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.
乙状结肠穿孔性憩室炎手术后发生严重术后坏疽性脓皮病的罕见病例。
Cureus. 2023 Mar 6;15(3):e35807. doi: 10.7759/cureus.35807. eCollection 2023 Mar.
4
Treatment Strategy for Pyoderma Gangrenosum: Skin Grafting with Immunosuppressive Drugs.坏疽性脓皮病的治疗策略：联合免疫抑制药物的皮肤移植术
J Clin Med. 2022 Nov 24;11(23):6924. doi: 10.3390/jcm11236924.
5
Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting.口服泼尼松龙、负压封闭引流联合植皮术成功治疗溃疡性坏疽性脓皮病
Case Rep Dermatol. 2021 Oct 21;13(3):497-501. doi: 10.1159/000519659. eCollection 2021 Sep-Dec.
坏疽性脓皮病两种最常用治疗方法的比较：STOP GAP随机对照试验的结果
BMJ. 2015 Jun 12;350:h2958. doi: 10.1136/bmj.h2958.
4
Corticosteroids and wound healing: clinical considerations in the perioperative period.皮质类固醇与伤口愈合：围手术期的临床注意事项。
Am J Surg. 2013 Sep;206(3):410-7. doi: 10.1016/j.amjsurg.2012.11.018. Epub 2013 Jun 4.
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Etiology and management of pyoderma gangrenosum: a comprehensive review.坏疽性脓皮病的病因和治疗：全面综述。
Am J Clin Dermatol. 2012 Jun 1;13(3):191-211. doi: 10.2165/11595240-000000000-00000.
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