Merčep Elena, Deán-Ben Xosé Luís, Razansky Daniel
Faculty of Medicine, Technical University of Munich, Germany.
iThera Medical GmbH, Munich, Germany.
Photoacoustics. 2018 Apr 27;10:48-53. doi: 10.1016/j.pacs.2018.04.002. eCollection 2018 Jun.
Changes in hemodynamic parameters are directly linked to biological function and physiological activity. Characterization of hemodynamics is commonly performed by Doppler ultrasound, which provides accurate measurements of blood flow velocity. Multi-spectral optoacoustic tomography is rapidly undergoing clinical translation fostered by its unique and complementary capacity for label-free mapping of the blood volume and the distribution of oxy- and deoxy-hemoglobin in blood. Here we report on a hybrid optoacoustic and ultrasound imaging approach that enables multi-modal imaging of blood flow and oxygen state using a multi-segment detector array. We further demonstrate rendering of multi-modal pulse-echo ultrasound, multi-spectral optoacoustic tomography, and color Doppler images from carotid artery of a healthy subject.
血流动力学参数的变化与生物功能和生理活动直接相关。血流动力学的表征通常通过多普勒超声进行，它能提供准确的血流速度测量。多光谱光声断层扫描因其在无标记绘制血容量以及血液中氧合血红蛋白和脱氧血红蛋白分布方面具有独特且互补的能力，正迅速走向临床应用。在此，我们报告一种光声和超声混合成像方法，该方法使用多段探测器阵列实现对血流和氧状态的多模态成像。我们还进一步展示了来自健康受试者颈动脉的多模态脉冲回波超声、多光谱光声断层扫描和彩色多普勒图像的呈现。
