Sugiura H, Hayashi M, Shimamura M, Matsubara F
Department of Pathology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Acta Pathol Jpn. 1987 Dec;37(12):1973-7. doi: 10.1111/j.1440-1827.1987.tb03311.x.
Nonspecific simple eosinophilic granulomatous prostatitis is extremely rare and in the present paper, the first case showing eosinophilia in the peripheral blood is reported. The patient was a 55-year-old Japanese man who was admitted because of difficulty in urination over a period of several years. The laboratory findings revealed marked eosinophilia (36%) in the peripheral blood, but the patient's past history showed neither bronchial asthma nor any allergic tendency. Transurethral resection of the prostate was performed and the histopathologic findings revealed a picture of non-caseating granulomatous prostatitis with massive eosinophilic infiltration without fibrinoid necrosis or vasculitis. Fragments of the prostatic urethra also showed the same findings. No fungus, bacterium or parasite was found. Although remnants of smooth muscle fibers were noted in the granulomas, neither immunoglobulins nor complement components could be demonstrated, and the etiology remained undetermined.
非特异性单纯嗜酸性粒细胞肉芽肿性前列腺炎极为罕见，本文报道了首例外周血嗜酸性粒细胞增多的病例。患者为一名55岁的日本男性，因数年排尿困难入院。实验室检查结果显示外周血嗜酸性粒细胞显著增多（36%），但患者既往史中既无支气管哮喘也无任何过敏倾向。行前列腺经尿道切除术，组织病理学检查结果显示为非干酪样肉芽肿性前列腺炎，伴有大量嗜酸性粒细胞浸润，无纤维蛋白样坏死或血管炎。前列腺尿道碎片也显示相同结果。未发现真菌、细菌或寄生虫。尽管在肉芽肿中发现了平滑肌纤维残余，但未检测到免疫球蛋白或补体成分，病因仍未明确。
