Parkhi Mayur, Singh Charanpreet, Kumar Rajender, Malhotra Pankaj, Bal Amanjit
Post Graduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.
Post Graduate Institute of Medical Education and Research, Department of Clinical hematology, Chandigarh, India.
Autops Case Rep. 2021 Aug 20;11:e2021296. doi: 10.4322/acr.2021.296. eCollection 2021.
Anaplastic lymphoma kinase (ALK) positive, anaplastic large cell lymphoma involving the non-mammary implant is an extremely rare presentation. Irrespective of the type or site, the implant-associated primary ALCL is morphologically and immunophenotypically similar to ALK-negative ALCLs. Herein, we present the case of a 42-year-old male who developed a lytic lesion after an implant for a right femur fracture. The lytic lesion biopsy revealed anaplastic large cell lymphoma with ALK protein expression. Imaging findings showed the widespread dissemination of disease all over the body, entrapping the implant too. ALCL involving the bone implant is a very unusual and rare presentation that needs to be documented.
间变性淋巴瘤激酶（ALK）阳性、累及非乳腺植入物的间变性大细胞淋巴瘤是一种极为罕见的表现。无论类型或部位如何，植入物相关的原发性间变性大细胞淋巴瘤在形态学和免疫表型上与ALK阴性的间变性大细胞淋巴瘤相似。在此，我们报告一例42岁男性，其在右股骨骨折植入物后出现溶骨性病变。溶骨性病变活检显示为具有ALK蛋白表达的间变性大细胞淋巴瘤。影像学检查结果显示疾病全身广泛播散，植入物也被累及。累及骨植入物的间变性大细胞淋巴瘤是一种非常不寻常且罕见的表现，需要记录在案。
