最脆弱人群中的百日咳：卡塔尔三个月以下婴儿百日咳病例系列
Whooping cough in the most vulnerable: A case series of pertussis in infants younger than three months in Qatar.
作者信息
Alesali Mohammad, Elhamidi Mohammad
机构信息
Pediatric Department, Al Khor Hospital, Hamad Medical Corporation, Doha, Qatar.
Clinical Science Department, College of Medicine, Qatar University, Doha, Qatar*Correspondence: Mohammad Alesali. Email:
出版信息
Qatar Med J. 2025 Mar 4;2025(1):18. doi: 10.5339/qmj.2025.18. eCollection 2025.
BACKGROUND
Pertussis, a highly contagious disease, has made a resurgence following the easing of COVID-19 pandemic restrictions. Infants under three months old are particularly vulnerable due to their immature immune systems and lack of protective vaccination.
METHODS
This study presents a case series of four infants, aged one to three months, who initially presented with nonspecific respiratory symptoms at Alkhor Hospital between January and June 2024. Subsequent diagnostic testing confirmed pertussis in all four cases. It is noteworthy that all cases involved were previously healthy infants with no underlying health conditions. Additionally, none of the mothers had received the Tdap vaccine during pregnancy.
RESULTS
All infants required hospitalization, with one being admitted to the PICU for eight days. Ultimately, all four infants made a full recovery.
CONCLUSION
Pertussis remains a significant cause of morbidity and mortality in infants under three months of age. Given the potential for severe complications and the burden it places on the healthcare system during outbreaks, it is crucial to emphasize preventive measures such as maternal vaccination.
背景
百日咳是一种高度传染性疾病，在新冠疫情限制措施放宽后有所复发。三个月以下的婴儿因其免疫系统不成熟且缺乏保护性疫苗接种而特别易受影响。
方法
本研究呈现了一个包含四名年龄在一至三个月的婴儿的病例系列，这些婴儿于2024年1月至6月期间在阿尔霍尔医院最初表现出非特异性呼吸道症状。随后的诊断测试在所有四例中均确诊为百日咳。值得注意的是，所有涉及的病例均为先前健康、无潜在健康问题的婴儿。此外，所有母亲在孕期均未接种破伤风类毒素、白喉、百日咳疫苗（Tdap）。
结果
所有婴儿均需住院治疗，其中一名婴儿在儿科重症监护病房（PICU）住院八天。最终，所有四名婴儿均完全康复。
结论
百日咳仍然是三个月以下婴儿发病和死亡的重要原因。鉴于爆发期间严重并发症的可能性及其给医疗系统带来的负担，强调诸如孕产妇疫苗接种等预防措施至关重要。
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