pH响应性DNA基序：从理性设计到分析应用
pH-Responsive DNA Motif: From Rational Design to Analytical Applications.
作者信息
Zheng Lin Lin, Li Jin Ze, Li Ying Xu, Gao Jian Bang, Dong Jiang Xue, Gao Zhong Feng
机构信息
Shandong Province Key Laboratory of Detection Technology for Tumor Makers, Collaborative Innovation Center of Tumor Marker Detection Technology, School of Chemistry and Chemical Engineering, Feixian Campus, Linyi University, Linyi, China.
College of Chemistry and Environmental Science, Key Laboratory of Analytical Science and Technology, Hebei University, Baoding, China.
出版信息
Front Chem. 2021 Aug 11;9:732770. doi: 10.3389/fchem.2021.732770. eCollection 2021.
pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence of specific protonation sites. In this review, we briefly summarized second structure-based pH-responsive DNA motifs, including triplex DNA, i-motif, and A-C mismatch base pair-based DNA devices. Finally, the challenges and prospects of pH-responsive DNA motifs are also discussed.
pH响应性DNA基序因其高度的可设计性和DNA化学的多功能性而备受关注。这类DNA基序通常利用由于存在特定质子化位点而具有pH响应特性的DNA二级结构。在本综述中，我们简要总结了基于二级结构的pH响应性DNA基序，包括三链DNA、i-基序和基于A-C错配碱基对的DNA装置。最后，还讨论了pH响应性DNA基序面临的挑战和前景。
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