步行能量学与β淀粉样蛋白状态的关联：来自巴尔的摩纵向衰老研究的结果
Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.
作者信息
Dougherty Ryan J, Ramachandran Janani, Liu Fangyu, An Yang, Wanigatunga Amal A, Tian Qu, Bilgel Murat, Simonsick Eleanor M, Ferrucci Luigi, Resnick Susan M, Schrack Jennifer A
机构信息
Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.
Departments of Epidemiology and Biostatistics Boston University School of Public Health Boston Massachusetts USA.
出版信息
Alzheimers Dement (Amst). 2021 Aug 20;13(1):e12228. doi: 10.1002/dad2.12228. eCollection 2021.
INTRODUCTION
Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/-) in older adults.
METHODS
One hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and C-Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4.
RESULTS
Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; = .011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; = .321).
DISCUSSION
High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.
引言
更高的运动能量消耗预示着步态速度下降。步态缓慢与认知能力下降和阿尔茨海默病（AD）相关。步行的能量消耗是否与AD病理相关尚不清楚。我们研究了老年人步行能量消耗、步态速度与淀粉样蛋白β（Aβ）状态（+/-）之间的横断面关联。
方法
149名认知正常的成年人（56%为女性，平均年龄77.5±8.4岁）通过间接热量测定法和C-匹兹堡复合B正电子发射断层扫描完成了习惯步速的步行评估。逻辑回归模型检验了经人口统计学、身体成分、合并症和载脂蛋白Eε4调整后的关联。
结果
每增加0.01mL/kg/m的能量消耗，Aβ阳性的几率就会增加18%（优势比[OR]=1.18；95%置信区间[CI]：1.04至1.34；P=.011）。在研究步态速度时未观察到这些结果（OR=0.99；95%CI：0.97至1.01；P=.321）。
讨论
高步行能量消耗与AD病理相关，可能是治疗干预的潜在靶点。
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