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Activation of Ca -AMPK-mediated autophagy by ginsenoside Rg3 attenuates cellular senescence in human dermal fibroblasts.

作者信息

Kim Dasol, Yang Kyeong Eun, Kim Dong Won, Hwang Hui-Yun, Kim Jinyoung, Choi Jong-Soon, Kwon Ho Jeong

机构信息

Chemical Genomics Leader/Global Research Laboratory, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

Bio-Chemical Analysis Group, Center for Research Equipment, Korea Basic Science Institute, Daejeon, Republic of Korea.

出版信息

Clin Transl Med. 2021 Aug;11(8):e521. doi: 10.1002/ctm2.521.

DOI:10.1002/ctm2.521
PMID:34459133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8351519/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/3982d185ab60/CTM2-11-e521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/90260a17168b/CTM2-11-e521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/ddcae2026e05/CTM2-11-e521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/92717f9fa897/CTM2-11-e521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/3982d185ab60/CTM2-11-e521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/90260a17168b/CTM2-11-e521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/ddcae2026e05/CTM2-11-e521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/92717f9fa897/CTM2-11-e521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8351519/3982d185ab60/CTM2-11-e521-g004.jpg

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本文引用的文献

1
Stereoisomer-specific ginsenoside 20()-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling.立体异构体特异性人参皂苷20()-Rg3通过Akt-mTOR-沉默调节蛋白信号通路逆转人二倍体成纤维细胞的复制性衰老。
J Ginseng Res. 2020 Mar;44(2):341-349. doi: 10.1016/j.jgr.2019.08.002. Epub 2019 Aug 13.
2
Proteomic analyses reveal that ginsenoside Rg3() partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.蛋白质组学分析表明，人参皂苷Rg3通过诱导过氧化物还原酶，部分逆转人皮肤成纤维细胞中的细胞衰老。
J Ginseng Res. 2020 Jan;44(1):50-57. doi: 10.1016/j.jgr.2018.07.008. Epub 2018 Aug 13.
3
人参皂苷 Rg1 在神经疾病中的作用：从基础到临床。
Acta Pharmacol Sin. 2023 May;44(5):913-930. doi: 10.1038/s41401-022-01022-1. Epub 2022 Nov 15.
4
The Second Asia-Oceania Human Proteome Organization (AOHUPO) Online Education Series on the Renaissance of Clinical Proteomics: Biomarkers, Imaging and Therapeutics.第二届亚太人类蛋白质组组织（AOHUPO）临床蛋白质组学复兴在线教育系列：生物标志物、成像和治疗学。
Mol Cell Proteomics. 2022 Dec;21(12):100436. doi: 10.1016/j.mcpro.2022.100436. Epub 2022 Oct 26.
5
Forward single-cell sequencing into clinical application: Understanding of ageing and rejuvenation from clinical observation to single-cell solution.推动单细胞测序进入临床应用：从临床观察到单细胞解决方案对衰老与年轻化的理解
Clin Transl Med. 2022 May;12(5):e827. doi: 10.1002/ctm2.827.
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
重新定位驱虫药尼氯硝唑乙醇胺（NEN），用于治疗脂肪毒性。
Free Radic Biol Med. 2019 Jun;137:143-157. doi: 10.1016/j.freeradbiomed.2019.04.030. Epub 2019 Apr 26.
4
Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction.人参皂苷-Rg3诱导的自噬通量减轻人朊蛋白介导的神经毒性和线粒体功能障碍。
Oncotarget. 2016 Dec 27;7(52):85697-85708. doi: 10.18632/oncotarget.13730.
5
Autophagy maintains stemness by preventing senescence.自噬通过防止衰老来维持干细胞特性。
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Keap1 degradation by autophagy for the maintenance of redox homeostasis.自噬降解 KEAP1 以维持氧化还原平衡。
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Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence.愈合与损伤：细胞衰老的分子机制、功能及病理学
Mol Cell. 2009 Oct 9;36(1):2-14. doi: 10.1016/j.molcel.2009.09.021.
9
The regulation of AMP-activated protein kinase by upstream kinases.上游激酶对AMP激活的蛋白激酶的调控
Int J Obes (Lond). 2008 Sep;32 Suppl 4:S55-9. doi: 10.1038/ijo.2008.124.