Department of Oral Medicine, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Netherlands.
Department of Nephrology, Dianet Amsterdam, and Amsterdam UMC, Netherlands.
Clin Exp Dent Res. 2022 Feb;8(1):54-67. doi: 10.1002/cre2.479. Epub 2021 Aug 29.
In patients with end stage, renal disease a high rate of morbidity and mortality is present. Studies suggest that end stage renal disease may affect oral health. Therefore, the aim of this study was to perform a scoping review on periodontal disease, dental caries, xerostomia, and hyposalivation in end stage renal disease patients.
A literature search (in PubMed and Embase.com) was performed up to September 29, 2020, in collaboration with a medical information specialist. Included outcome variables were the community periodontal index, probing pocket depth, gingival index, bleeding on probing, decayed-missing-filled-teeth, carious-absent-obturated index, Xerostomia Inventory and the (un)stimulated whole salivary flow rate.
Forty three out of 1293 studies were included in the final review comprising 7757 end stage renal disease patients. The average age was 58.3 ± 29.4 years. 28.2%-78.8% of patients reported xerostomia and the (un)stimulated salivary flow rates were significantly lower. Higher community periodontal index scores were measured in end stage renal disease patients. More decayed-missing-filled-teeth were recorded, but no differences were found between groups.
Xerostomia and hyposalivation were highly prevalent in end stage renal disease patients. Patients have more deepened pockets, but an equal number of carious teeth compared to healthy controls.
终末期肾病患者的发病率和死亡率均较高。有研究表明,终末期肾病可能会影响口腔健康。因此,本研究旨在对终末期肾病患者的牙周病、龋齿、口干和唾液分泌减少进行系统评价。
与医学信息专家合作,对截至 2020 年 9 月 29 日在 PubMed 和 Embase.com 上进行的文献检索进行了评估。纳入的结局变量包括社区牙周指数、探诊深度、牙龈指数、探诊出血、患龋失补牙数、龋失补牙面数、口干量表和(非)刺激性全唾液流率。
从 1293 项研究中筛选出 43 项最终纳入本系统评价,共纳入 7757 例终末期肾病患者。患者的平均年龄为 58.3±29.4 岁。28.2%-78.8%的患者报告有口干症,(非)刺激性唾液流率明显较低。终末期肾病患者的社区牙周指数评分较高。记录到更多的龋齿缺失补牙数,但组间无差异。
口干和唾液分泌减少在终末期肾病患者中较为常见。与健康对照组相比,患者的牙周袋较深,但龋齿数量相同。