Institute of Bioengineering and Bioimaging, 31 Biopolis Way, The Nanos, Singapore, 138669.
National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442.
ChemMedChem. 2021 Dec 6;16(23):3553-3558. doi: 10.1002/cmdc.202100504. Epub 2021 Sep 24.
In the search for a fast contact-killing antimicrobial surface to break the transmission pathway of lethal pathogens, nanostructured copper surfaces were found to exhibit the desired antimicrobial properties. Compared with plain copper, these nanostructured copper surfaces with Cu(OH) nano-sword or CuO nano-foam were found to completely eliminate pathogens at a fast rate, including clinically isolated drug resistant species. Additionally these nanostructured copper surfaces demonstrated potential antiviral properties when assessed against bacteriophages, as a viral surrogate, and murine hepatitis virus, a surrogate for SARS-CoV-2. The multiple modes of killing, physical killing and copper ion mediated killing contribute to the superior and fast kinetics of antimicrobial action against common microbes, and ESKAPE pathogens. Prototypes for air and water cleaning with current nanostructured copper surface have also been demonstrated.
在寻找一种快速接触杀菌的抗菌表面来阻断致命病原体的传播途径时,发现纳米结构的铜表面具有所需的抗菌特性。与普通铜相比,这些具有 Cu(OH)纳米剑或 CuO 纳米泡沫的纳米结构铜表面能够快速彻底消灭病原体,包括临床分离的耐药菌株。此外,当这些纳米结构铜表面针对噬菌体(病毒的替代物)和鼠肝炎病毒(SARS-CoV-2 的替代物)进行评估时,它们表现出潜在的抗病毒特性。多种杀菌模式,包括物理杀菌和铜离子介导的杀菌,有助于对常见微生物和 ESKAPE 病原体进行快速高效的抗菌作用。目前还展示了使用纳米结构铜表面进行空气和水清洁的原型。