Horita H, Kumagai K, Maekawa K
Division of Neurology, Saitama Children's Medical Center, Iwatsuki, Japan.
Brain Dev. 1987;9(6):627-35. doi: 10.1016/s0387-7604(87)80098-0.
Nine children with Lennox-Gastaut syndrome, aged 2-14 years, were studied by overnight polygraphy for one night. Percentage of sleep period time (SPT) for stage rapid eye movement (REM) and REM density during REM sleep decreased in Lennox-Gastaut syndrome as compared with control. Alpha rhythm was seen in only 3 cases and sleep spindles in only 6 cases. The effect of sleep-wake or REM-non-REM (NREM) sleep rhythm on the rate of generalized epileptiform discharges varied with the individual. Ictal discharges with or without clinical tonic seizures observed in 5 children appeared during NREM sleep and awakening in the morning, and in 2 of these cases they also occurred frequently during the NREM sleep of the first sleep cycle. Subclinical ictal discharges were also seen during REM sleep in the early morning in one case who was 2 years old. The Lennox-Gastaut syndrome is assumed to involved a considerable degree of brain stem dysfunction.
对9名年龄在2至14岁的Lennox-Gastaut综合征患儿进行了为期一晚的夜间多导睡眠图研究。与对照组相比，Lennox-Gastaut综合征患儿快速眼动（REM）期睡眠时间（SPT）百分比及REM睡眠期的REM密度降低。仅3例出现α波，仅6例出现睡眠纺锤波。睡眠-觉醒或REM-非快速眼动（NREM）睡眠节律对全身性癫痫样放电频率的影响因人而异。5名儿童中观察到的伴有或不伴有临床强直发作的发作期放电出现在NREM睡眠期和早晨觉醒时，其中2例在第一个睡眠周期的NREM睡眠期也频繁出现。1名2岁患儿在清晨REM睡眠期也出现了亚临床发作期放电。Lennox-Gastaut综合征被认为涉及相当程度的脑干功能障碍。
