Amir N, Shalev R S, Steinberg A
Neurology. 1986 Sep;36(9):1224-6. doi: 10.1212/wnl.36.9.1224.
Serial polysomnograms were performed on 11 children with primary Lennox-Gastaut syndrome (LGS), 6 control children with other seizure disorders, and 12 who were developmentally normal. Five LGS children had abnormal polysomnograms with either complete absence or marked reduction of REM sleep; the other six LGS children had only a mild reduction of REM sleep. The percentage of REM in LGS children was less than in the controls with other seizure disorders (p less than 0.05) or the normal children (p less than 0.005). The scatter of REM percentages in LGS may imply heterogeneity of the syndrome, perhaps related to the severity of brainstem dysfunction or neurochemical derangement.
对11名原发性Lennox-Gastaut综合征（LGS）患儿、6名患有其他癫痫疾病的对照儿童以及12名发育正常的儿童进行了连续多导睡眠图检查。5名LGS患儿的多导睡眠图异常，快速眼动睡眠完全缺失或显著减少；另外6名LGS患儿的快速眼动睡眠仅有轻度减少。LGS患儿的快速眼动睡眠百分比低于患有其他癫痫疾病的对照儿童（p<0.05）或正常儿童（p<0.005）。LGS患儿快速眼动睡眠百分比的离散情况可能意味着该综合征的异质性，或许与脑干功能障碍或神经化学紊乱的严重程度有关。
