Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran.
Clin Exp Optom. 2022 Sep;105(7):726-732. doi: 10.1080/08164622.2021.1969213. Epub 2021 Aug 29.
The existence of a correlation between the results of paraclinical retinal imaging and clinical tests such as contrast sensitivity can reduce time and cost in diagnosing optic neuritis (ON).
To demonstrate whether changes of peripapillary retinal nerve fibre layer (RNFL) thickness are correlated with the results of visual acuity, contrast sensitivity and colour vision in eyes with acute ON.
Thirty patients with acute ON, 23 females and seven males, who had no previous history of ON in neither eye, were examined. Inclusion criteria were: subjects had spherical refraction of less than ±5D, no prior ON or optic disc swelling, no history of amblyopia or colour blindness, and no history or ophthalmoscopic evidence of glaucoma, diabetic retinopathy, or maculopathies. Visual acuity, contrast sensitivity and colour vision were tested and optical coherence tomography was performed for all patients after complete ophthalmologic examinations including refraction, biomicroscopy, and funduscopy with a 90D lens by a neuro-ophthalmologist.
Thirty patients who were 18-45 years old entered the study. There was an inverse correlation between contrast sensitivity and nasal (r = -0.430, p = 0.018), inferior (r = -0.503, p = 0.005) and mean (r = -0.510, p = 0.004) RNFL thickness. The multiple linear regression model, after adjustment for age and sex, showed a significant association between visual acuity and nasal RNFL thickness (coefficient = 0.025, p = 0.032). There was also a significant inverse correlation between contrast sensitivity and nasal (coefficient = -0.003, p = 0.036), inferior (coefficient = -0.006, p = 0.010) and mean (coefficient = -0.007, p = 0.012) RNFL thickness. No significant correlation was found between colour vision and RNFL thickness.
Contrast sensitivity is more correlated with changes in RNFL thickness in comparison with visual acuity and colour vision. Contrast sensitivity measurement therefore can be used as one of the first assessments in patients with ON.
临床测试（如对比敏感度）与辅助检查（如视网膜成像）之间的相关性可以减少视神经炎（ON）的诊断时间和成本。
本研究旨在证明急性 ON 患者的视盘周围视网膜神经纤维层（RNFL）厚度变化与视力、对比敏感度和色觉结果之间是否存在相关性。
纳入了 30 名单侧急性 ON 患者，女性 23 名，男性 7 名，所有患者双眼均无 ON 病史。纳入标准为：患者球镜屈光度小于±5D，无 ON 或视盘肿胀病史，无弱视或色盲病史，无青光眼、糖尿病视网膜病变或黄斑病变的病史或眼科证据。所有患者在眼科检查（包括屈光、生物显微镜和 90D 镜眼底检查）后，由神经眼科医生进行视力、对比敏感度和色觉测试以及光学相干断层扫描。
本研究共纳入 30 名年龄在 18-45 岁之间的患者。对比敏感度与鼻侧（r=-0.430，p=0.018）、下侧（r=-0.503，p=0.005）和平均（r=-0.510，p=0.004）RNFL 厚度呈负相关。多因素线性回归模型校正年龄和性别后，显示视力与鼻侧 RNFL 厚度呈显著相关（系数=0.025，p=0.032）。此外，对比敏感度与鼻侧（系数=-0.003，p=0.036）、下侧（系数=-0.006，p=0.010）和平均（系数=-0.007，p=0.012）RNFL 厚度呈显著负相关。色觉与 RNFL 厚度无显著相关性。
与视力和色觉相比，对比敏感度与 RNFL 厚度变化的相关性更强。因此，对比敏感度测量可以作为 ON 患者的初步评估之一。
