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心脏肌钙蛋白和 B 型利钠肽在 COVID-19 中的应用。

The use of cardiac troponins and B-type natriuretic peptide in COVID-19.

机构信息

Department of Cardiology, Ghent University Hospital, Ghent, Belgium.

Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.

出版信息

Acta Cardiol. 2022 Sep;77(7):567-572. doi: 10.1080/00015385.2021.1970403. Epub 2021 Aug 30.

Abstract

Coronavirus disease 2019 (COVID-19) is still challenging health care systems worldwide. Over time, it has become clear that respiratory disease is not the only important entity as critically ill patients are also more prone to develop complications, such as acute cardiac injury. Despite extensive research, the mainstay of treatment still relies on supportive care and targeted therapy of these complications. The development of a prognostic model which helps clinicians to diverge patients to an appropriate level of care is thus crucial. As a result, several prognostic markers have been studied in the past few months. Among them are the cardiac biomarkers, especially cardiac troponins T/I and brain natriuretic peptide, which seem to have important prognostic values as several reports have confirmed their strong association with adverse clinical outcomes and death. The use of these biomarkers as part of a prognostic tool could potentially result in more precise risk stratification of COVID-19 patients and divergence to an adequate level of care. However, several caveats persist causing international guidelines to still recommend in favour of a more conservative approach to cardiac biomarker testing for prognostic purposes.

摘要

2019 年冠状病毒病(COVID-19)仍然对全球的医疗保健系统构成挑战。随着时间的推移,很明显,呼吸疾病并不是唯一重要的疾病实体,因为重症患者更容易出现并发症,如急性心脏损伤。尽管进行了广泛的研究,但治疗的主要方法仍然依赖于支持性护理和对这些并发症的靶向治疗。因此,开发一种有助于临床医生将患者分流到适当护理水平的预后模型至关重要。结果,过去几个月研究了几种预后标志物。其中包括心脏生物标志物,特别是心肌肌钙蛋白 T/I 和脑钠肽,由于有几项报告证实它们与不良临床结局和死亡有很强的关联,因此它们似乎具有重要的预后价值。将这些生物标志物用作预后工具的一部分,可能会导致对 COVID-19 患者进行更精确的风险分层,并分流到适当的护理水平。然而,仍然存在一些注意事项,导致国际指南仍然建议在预后目的上对心脏生物标志物检测采取更为保守的方法。

相似文献

1
The use of cardiac troponins and B-type natriuretic peptide in COVID-19.心脏肌钙蛋白和 B 型利钠肽在 COVID-19 中的应用。
Acta Cardiol. 2022 Sep;77(7):567-572. doi: 10.1080/00015385.2021.1970403. Epub 2021 Aug 30.

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