State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
BMJ Open. 2021 Aug 30;11(8):e045495. doi: 10.1136/bmjopen-2020-045495.
To investigate the association between body mass index (BMI) and all-cause mortality in a Chinese rural population.
Prospective cohort study.
This study was conducted from 2003 to 2018 in Anqing, Anhui Province, China.
17 851 participants aged 25-64 years (49.4% female) attending physical examinations and questionnaire were included in this study. The inclusion criterion was families having a minimum of three participating siblings. The exclusion criteria included participants without family number and BMI data at baseline.
The outcome measure was all-cause mortality. Generalized estimating equation (GEE) regression analysis was performed to determine the association between baseline BMI and all-cause mortality.
During a mean follow-up period of 14.1 years, 730 deaths (8.0%) occurred among men, and 321 deaths (3.6%) occurred among women. The mean BMI for males was 21.3[Formula: see text] kg/m, and for female it was 22.1±3.1 kg/m. Baseline BMI was significantly inversely associated with all-cause mortality risk for per SD increase (OR, 0.79 (95% CI, 0.72 to 0.87) for males; OR, 0.88 (95% CI, 0.76 to 1.01) for females). When BMI was stratified with cut points at 20 and 24 kg/m, compared with the low BMI group, a significantly lower risk of death was found in the high BMI group (BMI ≥24: OR, 0.57 (95% CI, 0.43 to 0.77) in males; 0.65 (95% CI, 0.46 to 0.93) in females) after adjustment for relevant factors.
In this relatively lean rural Chinese population, the risk of all-cause mortality decreased with increasing BMI. The excess risk of all-cause mortality associated with a high BMI was not seen among this rural population.
探讨中国农村人群体重指数（BMI）与全因死亡率之间的关系。
前瞻性队列研究。
本研究于 2003 年至 2018 年在中国安徽省安庆市进行。
本研究共纳入 17851 名年龄在 25-64 岁（49.4%为女性）、接受体检和问卷调查的参与者。纳入标准为至少有 3 名参与的兄弟姐妹的家庭。排除标准包括基线时无家族编号和 BMI 数据的参与者。
结局测量为全因死亡率。采用广义估计方程（GEE）回归分析确定基线 BMI 与全因死亡率之间的关系。
在平均 14.1 年的随访期间，男性有 730 例死亡（8.0%），女性有 321 例死亡（3.6%）。男性的平均 BMI 为 21.3[Formula: see text]kg/m，女性为 22.1±3.1 kg/m。基线 BMI 与全因死亡率风险呈显著负相关，每增加 1 SD（男性：OR，0.79（95%CI，0.72 至 0.87）；女性：OR，0.88（95%CI，0.76 至 1.01））。当 BMI 按 20 和 24 kg/m 进行分层时，与低 BMI 组相比，高 BMI 组的死亡风险显著降低（男性：BMI≥24：OR，0.57（95%CI，0.43 至 0.77）；女性：0.65（95%CI，0.46 至 0.93）），调整了相关因素后。
在这个相对较瘦的中国农村人群中，全因死亡率随 BMI 的增加而降低。在这个农村人群中，并未观察到 BMI 升高与全因死亡率之间存在过度风险。
