Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, Russia.
Sechenov University, Moscow, Russia.
Dokl Biol Sci. 2021 Jul;499(1):97-98. doi: 10.1134/S0012496621040050. Epub 2021 Aug 30.
The obtaining of microcarriers for the cell culture and delivery is an urgent task of tissue engineering and regenerative medicine. The novel method of surface modification of alginate microcarriers in the form of microspheres with a diameter of 200-300 μm was developed. The described method consists in covalent crosslinking between collagen and surface of alginate microcarriers. It was shown that the method makes it possible to completely modify the surface of the alginate microcarrier, which can be used to improve the biological properties of the microcarrier. Such microcarriers with improved biological properties can be considered as effective systems for cell delivery and culture.
获取用于细胞培养和递送的微载体是组织工程和再生医学的紧迫任务。开发了一种新颖的方法，以将直径为 200-300μm 的微球形式的藻酸盐微载体进行表面改性。所述方法包括胶原蛋白与藻酸盐微载体表面之间的共价交联。结果表明，该方法能够完全修饰藻酸盐微载体的表面，从而可以改善微载体的生物特性。具有改善的生物特性的此类微载体可以被认为是用于细胞递送和培养的有效系统。
