School of Nursing, Troy University, Troy, Alabama, USA.
College of Health and Human Services, Troy University, Troy, Alabama, USA.
Nutr Clin Pract. 2022 Jun;37(3):615-624. doi: 10.1002/ncp.10760. Epub 2021 Aug 31.
Patients with headand neck cancer (HNC) are at high risk for malnutrition before and during chemoradiation treatment. Many will also require tube feeding to address declines in energy intake, weight, and quality of life (QOL) caused by the impact of treatment on gastrointestinal (GI) symptoms. Blenderized tube feeding (BTF) may ameliorate these adverse conditions.
In this open-label, prospective pilot study, 30 patients with HNC who required feeding tube placement were recruited to switch from standard commercial formula after 2 weeks to a commercially prepared BTF formula. Weight, body mass index (BMI), GI symptoms, and QOL scores were tracked for 6 weeks from the first week of feeding tube placement.
Of the 16 patients who completed the 6-week assessment period, weights and BMI scores for 15 patients trended upward. For most patients, QOL and oral intake increased and GI symptoms decreased over the 6-week period, particularly during weeks 3 and 4, when the impact of treatment is particularly exacting on patients with HNC.
BTF effectively mitigated weight loss, GI symptoms, QOL scores, and total energy intake in this group of patients with HNC who received tube feeding for 6 weeks.
头颈部癌症（HNC）患者在放化疗前和期间存在营养不良的高风险。许多患者还需要通过管饲来解决因治疗对胃肠道（GI）症状的影响而导致的能量摄入、体重和生活质量（QOL）下降的问题。匀浆饮食管饲（BTF）可能改善这些不良状况。
在这项开放标签、前瞻性试点研究中，招募了 30 名需要放置喂养管的 HNC 患者，他们在 2 周后从标准商业配方转换为商业制备的 BTF 配方。从放置喂养管的第一周开始，跟踪体重、体重指数（BMI）、GI 症状和 QOL 评分 6 周。
在完成 6 周评估期的 16 名患者中，15 名患者的体重和 BMI 评分呈上升趋势。对于大多数患者，QOL 和口服摄入量在 6 周内增加，GI 症状减少，特别是在第 3 周和第 4 周，此时 HNC 患者的治疗影响尤其明显。
在接受管饲 6 周的 HNC 患者中，BTF 有效地减轻了体重减轻、GI 症状、QOL 评分和总能量摄入。
