Department of Biochemistry and Pharmacogenomics, Medical University of Warsaw, Warsaw, Poland.
Department of Pharmacology, Wroclaw Medical University, Wroclaw, Poland.
Drug Test Anal. 2021 Oct;13(10):1803-1806. doi: 10.1002/dta.3156. Epub 2021 Aug 30.
The use of specific medicine up to several months before a doping control is not be reported on the doping control form, while the drug could then still be detectable in urine in case of a very slow elimination. It may lead to a positive test result. For example, dorzolamide, a carbonic anhydrase inhibitor for topical ophthalmic application, has a very slow elimination rate via the renal route (half-life > 4 months). This substance can be a source of unintended anti-doping rule violations.
在兴奋剂检查前数月使用的特定药物无需在兴奋剂检查表上报告，但如果药物排泄非常缓慢，那么在尿液中仍可能被检测到。这可能导致阳性检测结果。例如，多佐胺，一种局部眼用碳酸酐酶抑制剂，通过肾脏途径的消除率非常缓慢（半衰期>4 个月）。这种物质可能是无意中违反反兴奋剂规则的来源。
