来自黄桐 Trichilia sinensis Bentv. 的具有 PTP1B 抑制活性的异戊烯基二氢查尔酮和黄烷型柠檬苦素
Khayalactone- and phragmalin-type limonoids with PTP1B inhibitory activity from Trichilia sinensis Bentv.
机构信息
Department of Pharmacy, College of Medicine, Jiaxing University, Jiaxing 314001, China.
Department of Pharmacy, College of Medicine, Jiaxing University, Jiaxing 314001, China; College of pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
Fitoterapia. 2021 Oct;154:105025. doi: 10.1016/j.fitote.2021.105025. Epub 2021 Aug 28.
An investigation on the extract from the plant Trichilia sinensis Bentv. led to the isolation of 13 new limonoids (1-13), in which two were of khayalactone skeleton and 11 were phragmalin-type limonoids, and eight known phragmalin-type limonoids (14-21). Their structures were elucidated by using spectroscopic techniques and HRESIMS experiment. Compounds 6 and 17 displayed potent protein tyrosine phosphatase 1B inhibitory activity with IC values of 1.2 ± 0.1 and 8.1 ± 0.5 μM, respectively.
对植物 Trichilia sinensis Bentv. 的提取物进行研究，分离得到了 13 种新的柠檬苦素（1-13），其中两种为 khayalactone 骨架，11 种为 phragmalin 型柠檬苦素，以及 8 种已知的 phragmalin 型柠檬苦素（14-21）。通过光谱技术和 HRESIMS 实验阐明了它们的结构。化合物 6 和 17 对蛋白酪氨酸磷酸酶 1B 具有较强的抑制活性，IC 值分别为 1.2 ± 0.1 和 8.1 ± 0.5 μM。
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