来自灰毛浆果楝的具有螺环骨架的四种柠檬苦素——浆果楝素A-D

Cipacinoids A-D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens.

作者信息

Yu Jin-Hai, Liu Qun-Fang, Sheng Li, Wang Guo-Cai, Li Jia, Yue Jian-Min

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P.R. China.

出版信息

Org Lett. 2016 Feb 5;18(3):444-7. doi: 10.1021/acs.orglett.5b03487. Epub 2016 Jan 13.

DOI:10.1021/acs.orglett.5b03487

PMID:26760061

Abstract

Four limonoids, cipacinoids A-D (1-4), with spirocyclic skeletons were isolated from Cipadessa cinerascens. It is particularly notable that compounds 1-3 had a 17S-configuration for the first time in the limonoid family. Their structures with absolute configurations were assigned by spectroscopic data, X-ray crystallography, and CD analysis. Compound 1 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibition.

摘要

从灰毛浆果楝中分离得到了四种具有螺环骨架的柠檬苦素类化合物，即浆果楝素A-D（1-4）。特别值得注意的是，化合物1-3在柠檬苦素家族中首次具有17S-构型。通过光谱数据、X射线晶体学和圆二色光谱分析确定了它们的结构及绝对构型。化合物1对蛋白酪氨酸磷酸酶1B（PTP1B）表现出中等程度的抑制作用。