来自中国香椿根的墨西哥内酯型柠檬苦素类化合物。

Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis.

作者信息

Liu Shou-Bai, Mei Wen-Li, Chen Hui-Qin, Guo Zhi-Kai, Dai Hao-Fu, Wang Zhu-Nian

机构信息

Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.

出版信息

Molecules. 2016 Aug 30;21(9):1152. doi: 10.3390/molecules21091152.

DOI:10.3390/molecules21091152

PMID:27589710

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6273291/

Abstract

Four new mexicanolide-type limonoids 1-4, along with two known limonoids 5-6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1-6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.

摘要

从传统中药华 Trichilia sinensis 的根乙醇提取物中分离出四种新的墨西哥内酯型柠檬苦素 1-4，以及两种已知的柠檬苦素 5-6。通过分析光谱数据（包括一维和二维核磁共振以及质谱）并与文献数据比较，明确确定了它们的结构。此外，采用 Ellman 法评估了化合物 1-6 的乙酰胆碱酯酶（AChE）抑制活性。所有这些化合物均表现出较弱的 AChE 抑制活性，抑制率范围为 18.5%至 27.8%。