Lyu Qian, Ma Linxiao, Liu Huijie, Shao Haiyan
Department of Rheumatology, The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People's Hospital of Lianyungang, Lianyungang, China.
Clin Rheumatol. 2025 Jan;44(1):133-141. doi: 10.1007/s10067-024-07179-w. Epub 2024 Nov 5.
The research examined the association between weight-adjusted waist index (WWI) and bone mineral density (BMD) in individuals with rheumatoid arthritis, considering the impact of obesity on bone health. The association between WWI and BMD was examined utilizing weighted linear regression and smoothed curve fitting with data from NHANES 2005-2010, 2013-2014, and 2017-2018. Subgroup analysis verified the stability of the results. The study included a cohort of 983 rheumatoid arthritis patients. A significant negative correlation was found between WWI and BMD at the total femur, femoral neck, and lumbar spine (β = -0.03, 95% CI (-0.04, -0.02), p < 0.001; β = -0.02, 95% CI (-0.04, -0.01), p = 0.001; β = -0.04, 95% CI (-0.06, -0.02), p < 0.001). This negative association was not significantly influenced by factors like age, gender, race, education, PIR, diabetes, hypertension, sleep disorders, alcohol consumption, or smoking status (p > 0.05 for interaction). The findings indicate a negative correlation between WWI and BMD in the rheumatoid arthritis population. Key Points •A negative correlation was found between WWI and BMD at the total femur, femoral neck, and lumbar spine in the rheumatoid arthritis population.
该研究考察了类风湿关节炎患者体重调整腰围指数（WWI）与骨密度（BMD）之间的关联，并考虑了肥胖对骨骼健康的影响。利用2005 - 2010年、2013 - 2014年和2017 - 2018年美国国家健康与营养检查调查（NHANES）的数据，通过加权线性回归和平滑曲线拟合来检验WWI与BMD之间的关联。亚组分析验证了结果的稳定性。该研究纳入了983名类风湿关节炎患者。在全股骨、股骨颈和腰椎处，WWI与BMD之间存在显著负相关（β = -0.03，95%置信区间（-0.04，-0.02），p < 0.001；β = -0.02，95%置信区间（-0.04，-0.01），p = 0.001；β = -0.04，95%置信区间（-0.06，-0.02），p < 0.001）。这种负相关不受年龄、性别、种族、教育程度、贫困收入比（PIR）、糖尿病、高血压、睡眠障碍、饮酒或吸烟状况等因素的显著影响（交互作用p > 0.05）。研究结果表明，类风湿关节炎人群中WWI与BMD之间存在负相关。要点•在类风湿关节炎人群中，全股骨、股骨颈和腰椎处的WWI与BMD之间存在负相关。
