de Boëver Raphaël, Langlois Adam, Li Xu, Claverie Jerome P
Department of Chemistry, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.
Institute of Materials Research and Engineering (ASTAR), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634.
JACS Au. 2021 May 11;1(6):843-851. doi: 10.1021/jacsau.1c00055. eCollection 2021 Jun 28.
Thanks to their photophysical properties, both organic molecular fluorophores (MFs) and inorganic quantum dots (QDs) are extensively used for bioimaging applications. However, limitations such as photobleaching for the former or blinking, size, and toxicity for the latter still constitute a challenge for numerous applications. We report here that embedding MFs in graphitic carbon dots (GDs) results in fluorophores which entirely tackle this challenge. Characterized by ultranarrow, bright, and excitation-independent emission devoid of blinking and photobleaching, these hybrid-featured nanoparticles also demonstrate their unique photophysical performances at the single-nanoparticle scale, making them appealing candidates for bioimaging applications.
由于其光物理性质,有机分子荧光团(MFs)和无机量子点(QDs)都被广泛用于生物成像应用。然而,前者的光漂白或后者的闪烁、尺寸和毒性等局限性仍然对众多应用构成挑战。我们在此报告,将MFs嵌入石墨碳点(GDs)中会产生完全应对这一挑战的荧光团。这些具有混合特征的纳米颗粒具有超窄、明亮且与激发无关的发射特性,无闪烁和光漂白现象,它们还在单纳米颗粒尺度上展示了独特的光物理性能,使其成为生物成像应用的有吸引力的候选者。