Stamm Gian-Marco, Sempoux Christine, Fraga Montserrat, Comte Denis, Aubert Vincent, Moradpour Darius, Vionnet Julien, Moschouri Eleni
Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne.
Institut universitaire de pathologie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2021 Sep 1;17(748):1457-1463.
Autoimmune hepatitis is a rare disease which can present as acute or chronic forms and can be difficult to diagnose due to its variable clinical presentation. The disease arises in genetically susceptible individuals and several triggers have been identified. The diagnosis is based on the presence of autoantibodies, elevated transaminases and serum immunoglobulin G levels as well as a compatible histology. First-line immunosuppressive treatment strategies lead to clinical remission in most patients. In case of non-response, second-line therapies can be used and in case of hepatocellular insufficiency, liver transplantation remains an excellent option.
自身免疫性肝炎是一种罕见疾病，可表现为急性或慢性形式，因其临床表现多样，可能难以诊断。该疾病发生于遗传易感性个体，且已确定多种触发因素。诊断基于自身抗体的存在、转氨酶和血清免疫球蛋白G水平升高以及相符的组织学表现。一线免疫抑制治疗策略可使大多数患者实现临床缓解。若治疗无反应，可采用二线疗法；若出现肝细胞功能不全，肝移植仍是一个极佳选择。
