George Laura Faith, Isner Trevor, Bates Emily Anne
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Bioelectricity. 2019 Mar 1;1(1):46-48. doi: 10.1089/bioe.2019.0003. Epub 2019 Mar 18.
How a single fertilized egg develops into a complex multicellular organism is one of the great mysteries of life. Developmental biology textbooks describe cascades of ligands, receptors, kinases, and transcription factors that designate proliferation, migration, and ultimately fate of cells organized into a multicellular organism. Recently, it has become apparent that ion channels are integral to the process of developmental signaling. Ion channels provide bioelectric signals that must intersect with the known developmental signaling pathways. We review some evidence that bioelectric signaling contributes to bone morphogenetic protein signaling.
一个受精卵如何发育成一个复杂的多细胞生物体是生命的重大奥秘之一。发育生物学教科书描述了一系列配体、受体、激酶和转录因子，它们决定了组成多细胞生物体的细胞的增殖、迁移以及最终命运。最近，很明显离子通道是发育信号传导过程中不可或缺的一部分。离子通道提供生物电信号，这些信号必须与已知的发育信号通路相互交叉。我们回顾了一些生物电信号传导有助于骨形态发生蛋白信号传导的证据。
