Sindeldecker Devin, Stoodley Paul
Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, USA.
Biofilm. 2021 Aug 21;3:100056. doi: 10.1016/j.bioflm.2021.100056. eCollection 2021 Dec.
is a bacterial pathogen associated with a wide range of infections and utilizes several strategies to establish and maintain infection including biofilm production, multidrug resistance, and antibiotic tolerance. Multidrug resistance in , as well as in all other bacterial pathogens, is a growing concern. Aminoglycoside resistance, in particular, is a major concern in infections and must be better understood in order to maintain effective clinical treatment. In this review, the various antibiotic resistance and tolerance mechanisms of are explored including: classic mutation driven resistance, adaptive resistance, persister cells, small colony variants, phoenix colonies, and biofilms. It is important to further characterize each of these phenotypes and continue to evaluate antibiotic surviving isolates for novel driving mechanisms, so that we are better prepared to combat the rising number of recurrent and recalcitrant infections.
是一种与多种感染相关的细菌病原体，并利用多种策略来建立和维持感染，包括生物膜形成、多药耐药性和抗生素耐受性。在以及所有其他细菌病原体中，多药耐药性日益受到关注。特别是氨基糖苷类耐药性，是感染中的一个主要问题，为了维持有效的临床治疗，必须更好地了解它。在这篇综述中，探讨了的各种抗生素耐药性和耐受性机制，包括：经典的突变驱动耐药性、适应性耐药性、持留菌、小菌落变体、凤凰菌落和生物膜。进一步表征这些表型中的每一种，并继续评估抗生素存活分离株的新驱动机制非常重要，这样我们就能更好地准备应对复发性和顽固性感染数量的增加。
