中性粒细胞在急性病毒感染中的作用。
Role of neutrophils in acute viral infection.
机构信息
Institute of Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing, China.
Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
出版信息
Immun Inflamm Dis. 2021 Dec;9(4):1186-1196. doi: 10.1002/iid3.500. Epub 2021 Sep 2.
Abstract
Neutrophils play multiple roles in acute viral infections. They restrict viral replication and diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and the release of neutrophil extracellular traps, as well as, activate the adaptive immune response. However, the overactivation of neutrophils may cause tissue damage and lead to poor outcomes. Additionally, some characteristics and functions of neutrophils, such as cell number, lifespan, and antiviral capability, can be influenced while eliminating viruses. This review provides a general description of the protective and pathological roles of neutrophils in acute viral infection.
摘要
中性粒细胞在急性病毒感染中发挥多种作用。它们通过吞噬作用、脱颗粒作用、呼吸爆发、细胞因子分泌和中性粒细胞细胞外陷阱的释放来限制病毒的复制和扩散，同时激活适应性免疫反应。然而，中性粒细胞的过度激活可能导致组织损伤，并导致不良后果。此外，在清除病毒的同时，中性粒细胞的一些特征和功能，如细胞数量、寿命和抗病毒能力，也可能受到影响。本综述概述了中性粒细胞在急性病毒感染中的保护和病理作用。
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