Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Metab Brain Dis. 2023 Dec;38(8):2505-2520. doi: 10.1007/s11011-023-01268-6. Epub 2023 Jul 24.
Intracerebral hemorrhage is a common neurological disease, and its pathological mechanism is complex. As the first recruited leukocyte subtype after intracerebral hemorrhage, neutrophils play an important role in tissue damage. In the past, it was considered that neutrophils performed their functions through phagocytosis, chemotaxis, and degranulation. In recent years, studies have found that neutrophils also have the function of secreting extracellular traps. Extracellular traps are fibrous structure composed of chromatin and granular proteins, which plays an important role in innate immunity. Studies have shown a large number of neutrophil extracellular traps in hematoma samples, plasma samples, and drainage samples after intracerebral hemorrhage. In this paper, we summarized the related mechanisms of neutrophil external traps and injury after intracerebral hemorrhage. Neutrophil extracellular traps are involved in the process of brain injury after intracerebral hemorrhage. The application of related inhibitors to inhibit the formation of neutrophil external traps or promote their dissolution can effectively alleviate the pathological damage caused by intracerebral hemorrhage.
脑出血是一种常见的神经系统疾病，其病理机制复杂。作为脑出血后第一募集的白细胞亚型，中性粒细胞在组织损伤中发挥重要作用。过去认为中性粒细胞通过吞噬、趋化和脱颗粒来发挥作用。近年来，研究发现中性粒细胞还具有分泌细胞外陷阱的功能。细胞外陷阱是由染色质和颗粒蛋白组成的纤维状结构，在先天免疫中发挥重要作用。研究表明，脑出血后血肿样本、血浆样本和引流样本中存在大量中性粒细胞细胞外陷阱。本文总结了中性粒细胞细胞外陷阱与脑出血后损伤的相关机制。中性粒细胞细胞外陷阱参与脑出血后的脑损伤过程。应用相关抑制剂抑制中性粒细胞细胞外陷阱的形成或促进其溶解，可有效减轻脑出血引起的病理损伤。
