血流感染病原菌念珠菌属的流行病学和抗真菌药敏分析：来自印度东部的研究视角。

Epidemiology and Antifungal Susceptibility of Candida Species causing Blood Stream Infections: An Eastern India Perspective.

机构信息

Assistant Professor, Medical College, Kolkata, West Bengal.

Assistant Professor, Department of Microbiology, IPGMER; 3Senior Resident, Medical College, Kolkata, West Bengal; Corresponding Author.

出版信息

J Assoc Physicians India. 2021 Aug;69(8):11-12.

PMID:34472809

Abstract

INTRODUCTION

Candidemia is the fourth common cause of blood stream infection worldwide leading to increased mortality and morbidity. A paradigm shift of Candida albicans to Non-albicans candida (NAC) had led to the increase in resistance to empirically used antifungals. So, an epidemiological study and antifungal susceptibility is essential for meticulous use of antifungals.

AIMS AND OBJECTIVES

To find out the prevalence and antifungal susceptibility of Candida species causing candidemia.

METHODS

automated blood culture done in BACTEC system followed by its identification and susceptibility testing in VITEK-2 system.

RESULTS

Non-albicans candida was isolated from 73% cases of candidemia. The commonest isolate among neonates and adults were C.krusei and C.tropicalis respectively. C.haemulonii was significantly high among adult population while C.krusei was significantly high among the neonates. 10.4% NAC isolates were resistant to amphotericin B, flucytosine resistance among 37% NAC isolates and among 44% C.albicans isolates, fluconazole resistance was found among 13% and 15% of NAC and C. albicans respectively. Echinocandins were comparatively sensitive to the candida spp.

摘要

简介

念珠菌血症是全球第四大常见的血流感染病因，可导致死亡率和发病率增加。白念珠菌向非白念珠菌（NAC）的转变导致了经验性使用的抗真菌药物的耐药性增加。因此，进行流行病学研究和抗真菌药敏试验对于精细使用抗真菌药物至关重要。

目的和目标

确定引起念珠菌血症的念珠菌属的流行情况和抗真菌药敏性。

方法

采用 BACTEC 系统进行自动化血液培养，然后在 VITEK-2 系统中进行鉴定和药敏试验。

结果

非白念珠菌从 73%的念珠菌血症病例中分离出来。新生儿和成人中最常见的分离株分别是克柔念珠菌和热带念珠菌。成人中 C. haemulonii 的比例明显较高，而新生儿中 C. krusei 的比例明显较高。10.4%的 NAC 分离株对两性霉素 B 耐药，37%的 NAC 分离株对氟胞嘧啶耐药，44%的 C. albicans 分离株对氟康唑耐药，NAC 和 C. albicans 分别有 13%和 15%的分离株对氟康唑耐药。棘白菌素类药物对念珠菌属相对敏感。