Feely J, Kelleher P, Odumosu A
Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland.
Fundam Clin Pharmacol. 1987;1(6):409-12. doi: 10.1111/j.1472-8206.1987.tb00574.x.
The influence of ageing on demethylation of 14C-aminopyrine (AP) and 14C-caffeine (Caf) in Wistar littermate rats was studied serially using the 14CO2-breath test. In both sexes, the elimination half-life (t1/2) of 14C-AP fell from a mean of approximately 75 min when weaned at 17 days to 45 min at maturity (49 days); thereafter t1/2 became prolonged, being most prolonged (82 min) in elderly male rats (210 days). Similarly, t1/2 of 14C-Caf was also prolonged with ageing. These studies using in vivo and longitudinal techniques indicate the importance of ageing on hepatic demethylation.
采用¹⁴CO₂呼气试验，对Wistar同窝大鼠进行连续研究，以探讨衰老对¹⁴C - 氨基比林（AP）和¹⁴C - 咖啡因（Caf）去甲基化的影响。在两性中，¹⁴C - AP的消除半衰期（t1/2）从17日龄断奶时的平均约75分钟降至成熟时（49日龄）的45分钟；此后t1/2延长，老年雄性大鼠（210日龄）延长最为明显（82分钟）。同样，¹⁴C - Caf的t1/2也随衰老而延长。这些采用体内和纵向技术的研究表明衰老对肝脏去甲基化具有重要影响。
