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制备环保型壳聚糖功能化少层 WS 纳米复合材料,植入钌纳米粒子,用于体外抗菌和抗癌活性:合成、表征和药物应用。

Fabrication of eco-friendly chitosan functionalized few-layered WS nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.

机构信息

Thin Film and Nanoscience Research Lab, PG and Research Department of Physics, Alagappa Government Arts College, Karaikudi 630 003, India.

Thin Film and Nanoscience Research Lab, PG and Research Department of Physics, Alagappa Government Arts College, Karaikudi 630 003, India.

出版信息

Int J Biol Macromol. 2021 Nov 1;190:520-532. doi: 10.1016/j.ijbiomac.2021.08.153. Epub 2021 Sep 1.

DOI:10.1016/j.ijbiomac.2021.08.153
PMID:34480908
Abstract

The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications. So, 2D nanomaterials are unique because of their physicochemical properties. Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community. In recent years numerous new 2D nanomaterials other than graphene have been reported. The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials. As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS and WS, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine. Herein, we synthesized biologically active CS/WS/Ru composite by liquid exfoliation approach. The CS/WS/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria. Also, the composite suggests synergetic anticancer action against MCF-7 cancer cells. These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.

摘要

二维(2D)材料的丰富性为构建纳米和原子级应用提供了广阔的材料平台。因此,2D 纳米材料具有独特的物理化学性质。多年来,石墨烯作为一种传统的二维层状元素,一直受到科学界的关注。近年来,除了石墨烯以外,还报道了许多其他的新型 2D 纳米材料。对 2D 纳米材料的研究还处于起步阶段,大多数研究都集中在解释特殊的材料特性上,但很少有文章关注 2D 纳米材料的生物应用。因此,我们专注于过渡金属二卤化物(TMDCs),如 MoS 和 WS,它们是新兴的、令人兴奋的元素组,在癌症纳米医学等多个领域具有巨大的应用机会。在此,我们通过液相剥离法合成了具有生物活性的 CS/WS/Ru 复合材料。CS/WS/Ru 复合材料对(金黄色葡萄球菌和大肠杆菌)细菌表现出显著的抗菌作用。此外,该复合材料对 MCF-7 癌细胞表现出协同的抗癌作用。这些报告可能会探索癌症应用中生物结果的创新方面。

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