Uganda Cancer Institute, Kampala, Uganda.
Department of Pathology, University of Cambridge, Cambridge, UK.
Lancet Haematol. 2021 Oct;8(10):e756-e769. doi: 10.1016/S2352-3026(21)00198-8. Epub 2021 Sep 2.
Haematological malignancies account for almost 10% of all cancers diagnosed in sub-Saharan Africa, although the exact incidences and treatment outcomes are difficult to discern because population-based cancer registries in the region are still underdeveloped. More research on haematological malignancies in sub-Saharan Africa is required to establish whether these cancers have a natural history similar to those diagnosed in high-income countries, about which more is known. Several factors negatively affect the outcome of haematological malignancies in sub-Saharan Africa, showcasing a need for improved understanding of the clinicobiological profile of these cancers to facilitate prevention, early detection, diagnosis, and appropriate treatment through increased capacity building, infrastructure, community awareness, coordinated resource mobilisation, and collaboration across the world. The east African governments have pooled resources for common investments to tackle non-communicable diseases, developing the East Africa's Centres of Excellence for Skills and Tertiary Education project funded by the African Development Bank, an initiative that could be replicated for the care of haematological malignancies in other countries in sub-Saharan Africa. TRANSLATION: For the French translation of the abstract see Supplementary Materials section.
在撒哈拉以南非洲，血液系统恶性肿瘤约占所有确诊癌症的 10%，尽管确切的发病率和治疗结果难以确定，因为该地区的基于人群的癌症登记处仍未充分发展。需要对撒哈拉以南非洲的血液系统恶性肿瘤进行更多的研究，以确定这些癌症是否具有与在高收入国家中诊断出的癌症相似的自然病史，而关于后者我们了解得更多。一些因素会对撒哈拉以南非洲的血液系统恶性肿瘤的治疗结果产生负面影响，这表明需要更好地了解这些癌症的临床生物学特征，以便通过加强能力建设、基础设施、社区意识、协调资源动员以及在全球范围内的合作，促进预防、早期发现、诊断和适当治疗。东非政府已经汇集资源进行共同投资，以应对非传染性疾病，正在实施由非洲开发银行资助的东非技能和高等教育卓越中心项目，这一举措可以在其他撒哈拉以南非洲国家中复制，用于血液系统恶性肿瘤的治疗。
